ascochlorin

ascochlorin Struktur
26166-39-2
CAS-Nr.
26166-39-2
Englisch Name:
ascochlorin
Synonyma:
Nsc 287492;ascochlorin;Ilicicolin D;Ll-Z 1272 gamma;Antibiotics LL-Z 1272g;Antibiotic ll-Z1272 gamma;LL-Z 1272 gaMMa, Ilicicolin D;beta-Resorcylaldehyde, 5-chloro-6-methyl-3-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)-, (E,E)-;5-Chloro-2,4-dihydroxy-6-methyl-3-[(2E,4Z)-3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)penta-2,4-dienyl]benzaldehyde;3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,4E)-3-methyl-5-[(1R)-1β,2β,6β-trimethyl-3-oxocyclohexyl]-2,4-pentadienyl]benzaldehyde
CBNumber:
CB01364846
Summenformel:
C23H29ClO4
Molgewicht:
404.931
MOL-Datei:
26166-39-2.mol

ascochlorin Eigenschaften

Schmelzpunkt:
172-174 °C
Siedepunkt:
556.9±39.0 °C(Predicted)
Dichte
1.199±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO: soluble
Aggregatzustand
A powder
pka
6.26±0.50(Predicted)

Sicherheit

WGK Germany  3
Toxizität mouse,LD50,intraperitoneal,20mg/kg (20mg/kg),Journal of Antibiotics. Vol. 21, Pg. 539, 1968.

ascochlorin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Ascochlorin is an antitumor fungal metabolite which specifically inhibits matrix metalloproteinase-9 (MMP-9) activity through suppression of activator protein-1 (AP-1)-dependent induction of MMP-9 gene expression. Via AP-1 suppression, ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.

ascochlorin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ascochlorin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 28)Lieferanten
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  • 3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,4E)-3-methyl-5-[(1R)-1β,2β,6β-trimethyl-3-oxocyclohexyl]-2,4-pentadienyl]benzaldehyde
  • Ilicicolin D
  • 3-Chloro-4,6-dihydroxy-2-methyl-5-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)benzaldehyde (1R-(1alpha(2E,4E),2beta,6beta))-
  • Antibiotic ll-Z1272 gamma
  • ascochlorin
  • Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)-, (1R-(1alpha(2E,4E),2beta,6beta))-
  • beta-Resorcylaldehyde, 5-chloro-6-methyl-3-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)-, (E,E)-
  • Ll-Z 1272 gamma
  • Nsc 287492
  • LL-Z 1272 gaMMa, Ilicicolin D
  • 5-Chloro-2,4-dihydroxy-6-methyl-3-[(2E,4Z)-3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)penta-2,4-dienyl]benzaldehyde
  • Antibiotics LL-Z 1272g
  • Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,4E)-3-methyl-5-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]-2,4-pentadien-1-yl]-
  • 26166-39-2
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