N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

• as a cathepsin B substrate in zymography analysis of protease in feces extract.
• in cathepsin B activity assay.
• as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

Allgemeine Beschreibung

Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.

Biochem/physiol Actions

Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9030	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3000	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9823	79
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	16168	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919	eric@peptidego.com	China	6526	58

136132-67-7()Verwandte Suche:

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• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL
• Z-ARG-ARG-AMC 2HCL
• Z-ARG-ARG-AMC HYDROCHLORIDE SALT
• Z-ARG-ARG-MCA HYDROCHLORIDE
• Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
• Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL
• Z-RR-AMC, 2HCL
• z-arg-arg-7-amido-4-methylcoumarin hydrochloride
• z-rr-amc
• Z-ARG-ARG-MCA.HCL
• ANTI-CATB (CENTER) antibody produced in rabbit
• APP secretase
• CPSB
• CTSB
• Cathepsin B Active human
• BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
• CATHEPSIN B SUBSTRATE III, FLUOROGENIC
• CATHEPSIN B SUBSTRATE IV, FLUOROGENIC
• na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo
• NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI
• N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU
• Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC
• Z-Arg-Arg-AMC/Z-RR-AMC
• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP
• Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag
• Recombinant Human Cathepsin B/CTSB Protein, His Tag
• Z-Arg-Arg-7-amido-4-methylcoumarin
• CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride
• Mouse Anti-Caspase 8 antibody
• Z-Arg-Arg-AMC hydrochloride
• 136132-67-7
• C30H39N9O6
• C30H41Cl2N9O6
• C30H39N9O6HCl
• Cathepsins and Granzymes
• Cathepsin B
• Caspases
• Caspase 8
• Cell Signaling and Neuroscience
• Cell Biology
• Apoptosis and Cell Cycle
• BioChemical
• Substrates
• Substrates