VU0155041 sodium salt

VU0155041 sodium salt Struktur
1259372-69-4
CAS-Nr.
1259372-69-4
Englisch Name:
VU0155041 sodium salt
Synonyma:
VU0155041 sodium;VU0155041 sodium salt;VU-0155041 sodium,VU0155041 sodium;cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacidsodiumsalt
CBNumber:
CB02487584
Summenformel:
C14H14Cl2NNaO3
Molgewicht:
338.162
MOL-Datei:
1259372-69-4.mol

VU0155041 sodium salt Eigenschaften

storage temp. 
Desiccate at RT
Löslichkeit
DMSO: 1 mg/ml; PBS (pH 7.2): 2 mg/ml
Aggregatzustand
Powder
Wasserlöslichkeit
Soluble to 25 mM in water

Sicherheit

VU0155041 sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

VU0155041 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with an EC50 value of 2.5 μM for glutamate response in a thallium flux assay. It is selective for mGluR4, exhibiting no effect on radioligand binding at 67 G protein-coupled receptors, ion channels, and transporters, and lacking antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. In vivo, VU0155041 decreases catalepsy induced by haloperidol and reverses askinesias induced by reserpine in rat models of Parkinson’s disease. Chronic treatment with VU0155041 restores social behavior in the Oprm-/- mouse model of autism. It also increases the percentage of time spent in the open arms of the elevated plus maze, a measure of decreased anxiety, in mice.

Verwenden

VU 0155041 Sodium Salt is a positive allosteric modulator of group III mGlu4 receptor that provides functional neuprotection in 6-hydroxydopamine rat models with parkinson’s disease.

VU0155041 sodium salt Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


VU0155041 sodium salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 18)Lieferanten
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TargetMol Chemicals Inc.
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Aladdin Scientific
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sales@aladdinsci.com United States 52927 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
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Ascent Scientific 4401179829988
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EMMX Biotechnology LLC 888-539-0666
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BOC Sciences --
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MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 23980 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 8736 58
United States Biological --
sales@advtechind.com United States 6106 58

  • VU0155041 sodium salt
  • cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacidsodiumsalt
  • VU0155041 sodium
  • VU-0155041 sodium,VU0155041 sodium
  • 1259372-69-4
  • C14H14Cl2NNaO3
  • Glutamate
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