PD0332991 Isethionate
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- CAS-Nr.
- 827022-33-3
- Englisch Name:
- PD0332991 Isethionate
- Synonyma:
- CS-1265;PD332991;PD 332991;PD-332991;PF 00080665-73;PD 0332991-0054;PD0332991 Isethiote;Palbociclib-019-Salt;PD0332991 Isethionate;Palbociclib (isethionate)
- CBNumber:
- CB02663078
- Summenformel:
- C26H35N7O6S
- Molgewicht:
- 573.67
- MOL-Datei:
- 827022-33-3.mol
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PD0332991 Isethionate Eigenschaften
- storage temp.
- room temp
- Löslichkeit
- ≥28.7 mg/mL in DMSO; insoluble in EtOH; ≥26.8 mg/mL in H2O
- Aggregatzustand
- powder
- Farbe
- white to beige
- CAS Datenbank
- 827022-33-3
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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PD0332991 Isethionate Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
PD 0332991 isethionate has been used:
- to incubate MCF10A cells to verify cyclin D1 inhibition of autophagy involved cyclin-dependent kinase activity
- as a cyclin dependent kinase 4 (CDK4) inhibitor to study its anticonvulsive property in Drosophila
- to mimic the inhibitory effect of 5α-dihydrotestosterone (DHT) on HPr-1AR cell cycle progression and growth
Biochem/physiol Actions
PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells.
PD0332991 Isethionate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PD0332991 Isethionate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 177)Lieferanten
827022-33-3()Verwandte Suche:
- PD0332991 Isethionate
- Palbociclib (PD0332991) Isethionate
- Palbociclib (isethionate)
- PD 0332991-0054
- PF 00080665-73
- Ethanesulfonic acid, 2-hydroxy-, compd. with 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one (1:1)
- PD0332991 Isethiote
- 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate
- Ethanesulfonic acid, 2-hydroxy-, compd. with 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidi
- palbociclib Isethionate 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one mono-isethionate salt
- Palbociclib-019-Salt
- Palbociclib Isethionate(PD0332991)
- 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one,2-hydroxyethanesulfonic acid
- Palbociclib Isethionate, brand name: Ibrance
- PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; PALBOCICLIB ISETHIONATE, BRAND NAME: IBRANCE
- PD 332991
- PD332991
- PD-332991
- 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt
- CS-1265
- Palbociclib-isethionate, PD0332991 isethionate
- Palbociclib impurity 20/Palbociclib Isethionate/6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one,2-hydroxyethanesulfonic acid
- PD 0332991 (Palbociclib) Isethionate
- PD 0332991 Isethionate
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- PD0332991 Isethionate USP/EP/BP
- PD 0332991 Isethionate
DISCONTINUED
- Palbociclib (PD0332991) Isethionate|||PD 0332991 isethionate
- 827022-33-3
- C26H35N7O6S
- C24H29N7O2C2H6O4S
- Inhibitors
- APIs
