Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

1402612-56-9

CAS-Nr.: 1402612-56-9

Englisch Name:: Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

Synonyma:: KT-172 (KT172);KT172 >=98% (HPLC);(2-benzylpiperidin-1-yl)-[4-[4-(2-methoxyphenyl)phenyl]triazol-1-yl]methanone;4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone;Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-

CBNumber:: CB02667551

Summenformel:: C28H28N4O2

Molgewicht:: 452.55

MOL-Datei:: 1402612-56-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 7

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]- Eigenschaften

Löslichkeit: DMF:5.0(Max Conc. mg/mL);10.72(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);21.43(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.25(Max Conc. mg/mL);0.55(Max Conc. mM)

Aggregatzustand: A crystalline solid

Farbe: Off-white to light yellow

Sicherheit

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ. It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ (IC₅₀s = 140 and 60 nM, respectively). KT172 also inhibits α/β-hydrolase 6 (ABHD6; IC₅₀ = 5 nM) and weakly inhibits monoacylglycerol lipase (MAGL; IC₅₀ = 5,000 nM) in a panel of 47 mouse serine hydrolases. It restores nicotine-stimulated GABA release in isolated ventral tegmental area (VTA) dopamine neurons from rats chronically exposed to nicotine when used at a concentration of 1 μM. KT172 decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), prostaglandin E₂ (PGE₂; ), and PGD₂ in thioglycolate-stimulated peritoneal macrophages when administered at a dose of 5 mg/kg in mice.

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 7)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Methanone, [4-(2'-Methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylMethyl)-1-piperidinyl]-
KT172 >=98% (HPLC)
KT-172 (KT172)
(2-benzylpiperidin-1-yl)-[4-[4-(2-methoxyphenyl)phenyl]triazol-1-yl]methanone
4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone
1402612-56-9