ML216

ML216 Struktur
1430213-30-1
CAS-Nr.
1430213-30-1
Englisch Name:
ML216
Synonyma:
ML216;CS-1561;CID49852229;CID 49852229;CID-49852229;ML216(CID4985229);ML216(CID-49852229);ML 216; ML-216; CID-49852229; CID49852229; CID 49852229;1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure;N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea
CBNumber:
CB02715652
Summenformel:
C15H9F4N5OS
Molgewicht:
383.32
MOL-Datei:
1430213-30-1.mol

ML216 Eigenschaften

Dichte
1.583±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)
pka
6.40±0.50(Predicted)
Aggregatzustand
powder
Farbe
light orange to dark orange
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 25
S-Sätze: 45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H413 Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

ML216 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.

Verwenden

ML216 has been used in cell proliferation assays.

Biochem/physiol Actions

ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase, a member of the RecQ DNA helicase family. Bloom′s syndrome, caused by a mutation in BLM, is associated with susceptibility to cancer, growth retardation, immunodeficiency, sunlight sensitivity, and fertility defects. ML216 is selective for BLM over other members of the RecQ family, especially in vivo, and appears to act at the BLM-nucleic acid substrate binding site, inhibiting DNA binding and blocking BLM′s helicase activity. ML216 could be useful in studies of tumor cells depending on the ALT (alternative lengthening of telomeres) mechanism for telomere maintenance rather than on telomerase, which are proposed to be susceptible to BLM inhibition.

ML216 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ML216 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 77)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32760 60
Chengdu Feibo Pharm Technology Co., Ltd
15982321820
abby@arkpharm.com CHINA 3279 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
Chemtour Biotech Co., Ltd
+8617327281506
market@chemtour.com China 1460 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8474 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 4692 58

1430213-30-1()Verwandte Suche:


  • ML216
  • 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea
  • N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea
  • CID 49852229
  • CID49852229
  • CID-49852229
  • ML 216; ML-216; CID-49852229; CID49852229; CID 49852229
  • CS-1561
  • ML216(CID-49852229)
  • ML216(CID4985229)
  • 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure
  • Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-
  • helicase,CID 49852229,WRN,DNA,sister,inhibit,Anticancer,ML-216,anti-proliferative,DNA/RNA Synthesis,Inhibitor,chromatid,CID49852229,BLM,unwinding,toxicity,ML 216,ML216
  • 1430213-30-1
  • C15H9F4N5OS
Copyright 2019 © ChemicalBook. All rights reserved