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N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan

PHOSPHORAMIDON Struktur
36357-77-4
CAS-Nr.
36357-77-4
Bezeichnung:
N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan
Englisch Name:
PHOSPHORAMIDON
Synonyma:
eucyl)-;yptophan;PHOSPHORAMIDON;PHOSPHORAMIDON SODIUM SALT;PHOSPHORAMIDON DISODIUM SALT DIHYDRATE;N-(A-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP;N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP-OH;N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP 2NA;N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP SODIUM SALT;N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN
CBNumber:
CB0324672
Summenformel:
C23H34N3O10P
Molgewicht:
543.51
MOL-Datei:
36357-77-4.mol
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N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan Eigenschaften

Dichte
1.48±0.1 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
H2O: 1 mM Stock solution stable for 1 month at –20° C.
pka
-0.66±0.50(Predicted)

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3
F  10-21

N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Definition

ChEBI: A dipeptide isolated from the cultures of Streptomyces tanashiensis.

Enzyminhibitor

This glycosyl phosphoramidopeptide (FWfree-acid = 543.51 g/mol; CAS 36357-77-4), also systematically named as N-(a-rhamnopyranosyloxyhydroxyphosphinyl)- L-leucyl-L-tryptophan, is a slow-binding thermolysin inhibitor (Ki = 30 nM). Note: Phosphoramidon is an epimer of talopeptin. Stock 1 mg/mL aqueous solutions of phosphoramidon are stable for one month at –20°C. Target(s): atrolysin A; atrolysin C; bacillolysin; carboxypeptidase C, weakly inhibited; coccolysin; cytosol alanyl aminopeptidase, weakly inhibited; dactylysin; endothelin-converting enzyme; endothelin-converting enzyme 2; fungalysin; gametolysin; granzyme B; Legionella metalloendopeptidase; leucyl aminopeptidase, weakly inhibited; Listeria metalloprotease Mpl; lysine carboxypeptidase, or lysine(arginine) carboxypeptidase; carboxypeptidase N; mycolysin; neprilysin, or enkephalinase, Ki = 0.8 nM; oligopeptidase O; peptidyl-dipeptidase A, or angiotensin I-converting enzyme; pitrilysin, or protease Pi; pseudolysin, or Pseudomonas aeruginosa elastase; pyruvate decarboxylase; thermolysin (27,28,41,43- 53); urethanase; vibriolysin; and Xaa-Pro aminopeptidase, or aminopeptidase P.

N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 35)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd 		+86-15542445688
sales@alabiochem.com China 888 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32165 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Wuhan Fortuna Chemical Co.,Ltd 		+8618007136271
 hk@fortunachem.com China 5998 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518
 sales@alabiochem.com China 997 59
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031
 cdhxsj@163.com China 11707 57
Codow Chemical Co.,Ltd. 18620099427
 amy@howeipharm.com China 17687 55
Shandong Xiya Chemical Co., Ltd. 4009903999 13395398332
 sales@xiyashiji.com China 20806 60
Alabiotech Inc. 001-619-354-5251
sales@alabiotech-e.com United States 972 60

36357-77-4(N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan)Verwandte Suche:

N-L-Alanyl-L-tryptophan N-[N-[[(6-Desoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan
  • N-(A-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP 2NA
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP-OH
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP SODIUM SALT
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, 2NA
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXY-PHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN DISODIUM SALT
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN DISODIUM SALT DIHYDRATE
  • N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN (SODIUM SALT)
  • N-(ALPHA-RHAMNOPYRANOSYLPHOSPHONO)-L-LEUCYL-L-TRYPTOPHAN DISODIUM SALT
  • N-[N-[[(6-deoxy-alpha-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan
  • N-[N-[(6-Deoxy-α-L-mannopyranosyloxy)hydroxyphosphinyl]-L-Leu-]-L-Trp-OH
  • L-Tryptophan,N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-
  • eucyl)-
  • l-tryptophan,n-(n-(((6-deoxy-alpha-l-mannopyranosyl)oxy)hydroxyphosphinyl)-l-l
  • n-(n-(((6-deoxy-alpha-l-mannopyranosyl)oxy)hydroxyphosphinyl)-l-leucyl)-l-tr
  • yptophan
  • PHOSPHORAMIDON
  • PHOSPHORAMIDON DISODIUM SALT DIHYDRATE
  • PHOSPHORAMIDON SODIUM SALT
  • L-Tryptophan, N-[[(6-deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-
  • 36357-77-4
  • BioChemical
  • Biochemicals and Reagents
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • P to Q
  • Phosphodiesterase 3',5'-Cyclic Nucleotide
  • Substrate Analogs
  • peptides
  • Pepetides
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