2,4,5-Triamino-6-hydroxypyrimidine sulfate
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- CAS-Nr.
- 35011-47-3
- Englisch Name:
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
- Synonyma:
- 2,5,6-Triamino-4(1H)-pyrimidinone sulfate;2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE HYDRATE;TAPOS;4-Hydr;NSC 167378;Folic acid Impurity 69;Folic Acid Impurity 26;Folic Acid Impurity B Sulfate;Folic Acid EP Impurity B Sulfate;2,5,6-Triamino-4-pyrimidol sulfate
- CBNumber:
- CB0447678
- Summenformel:
- C4H9N5O5S
- Molgewicht:
- 239.21
- MOL-Datei:
- 35011-47-3.mol
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2,4,5-Triamino-6-hydroxypyrimidine sulfate Eigenschaften
- Schmelzpunkt:
- ≥300 °C(lit.)
- RTECS-Nr.
- UW7175000
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- Soluble in DMSO.
- Aggregatzustand
- Solid
- Farbe
- Pale Yellow
- InChI
- InChI=1S/C4H7N5O.H2O4S/c5-1-2(6)8-4(7)9-3(1)10;1-5(2,3)4/h5H2,(H5,6,7,8,9,10);(H2,1,2,3,4)
- InChIKey
- RSKNEEODWFLVFF-UHFFFAOYSA-N
- SMILES
- NC1C(N=C(N)NC=1N)=O.S(O)(O)(=O)=O
- CAS Datenbank
- 35011-47-3(CAS DataBase Reference)
2,4,5-Triamino-6-hydroxypyrimidine sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
yellow-beige crystalline powder
Verwenden
2,4,5-Triamino-6-hydroxypyrimidine sulfate is used in the preparation of guanines and other purine derivatives with antiviral activities.
läuterung methode
This salt has very low solubility in H2O. It is best purified by conversion into the dihydrochloride salt, which is then re-converted to the insoluble sulfate salt. The sulfate salt (2.57g, 10mmoles) is suspended in H2O (20mL) containing BaCl2 (10mmoles) and stirred in a boiling water bath for 15minutes. After cooling, the insoluble BaSO4 is filtered off and washed with boiling H2O (10mL). The combined filtrate and washings are made acidic with HCl and evaporated to dryness. The residual hydrochloride salt is recrystallised from H2O by adding conc HCl whereby the dihydrochloride salt separates as clusters which darken at 260o and dec > 300o[darkening > 360o]. [Baugh & Shaw J Org Chem 29 3610 1964, King & Spengley J Chem Soc 2144 1952]. The hydrochloride is then dissolved in H2O, and while hot an equivalent of H2SO4 is added when the sulfate separates as a white microcrystalline solid which is filtered off washed liberally with H2O and dried in vacuum over P2O5. [Albert & Wood J Appl Chem London 3 521 1953, UV: Cavalieri et al. J Am Chem Soc 70 3875 1948; see also Pfleiderer Chem Ber 90 2272 1957, Traube Chem Ber 33 1371 1900.] The hydrochloride has m > 300o. [Beilstein 25 II 384, 25 III/IV 3648.]
2,4,5-Triamino-6-hydroxypyrimidine sulfate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,4,5-Triamino-6-hydroxypyrimidine sulfate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 379)Lieferanten
35011-47-3()Verwandte Suche:
- 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE SULFATE HYDRATE
- 2,5,6-TRIAMINO-4(1H)-PYRIMIDINONE SULFATE HYDRATE
- 4-HYDROXY-2,5,6-TRIAMINOPYRIMIDINE
- 4-hydroxy-2,5,6-triaminopyrimidine sulf. monohydr. (6-2,4,5)
- 2,5,6-triamino-4-pyrimidol sulfate salt
- 4-hydroxy-2,5,6-triaminopyrimidine sulfate salt
- 2,4,5-triamido-6-oxhydrylpyrimidine sulfate
- 4-HYDROXY-2,5,6-TRIAMINOPYRIMIDINE SULFATE 97+%
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate
- 2,5,6-Triamino-4-pyrimidol sulfate
- 2,4,5-Triamino-6-hydroxypyrimidine Sulfate Hydrate
- 6-Hydroxy-2,4,5-triaminopyrimidine sulfate,97%
- 4-Hydr
- 2,5,6-TriaMino-4(3H)-pyriMidinone Sulfate
- NSC 167378
- 2,5,6-TriaMinopyriMidin-4(3H)-one sulfate
- 2,5,6-Triaminopyrimidin-4-ol sulphate, 4-Hydroxy-2,5,6-triamino-1,3-diazine sulphate
- 4-Hydroxy-2,5,6-triaminopyrimidine sulphate
- 4-Hydroxy-2,5,6-triaminopyrimidine sulfate salt, >=97%
- 2,4,5-triamino-6-hydroxypyrimidine sulfate:2,5,6-triamino-4-pyrimidol sulfate
- 2,5,6-Triaminopyrimidin-4(1H)-one Sulfate
- 2,4,5 -TRIAMINO-6-HYDROXY PYRIMIDINE SULFATE 93% MIN
- 5-Triamino-6-hydroxypyrimidine sulfate
- Folic acid Impurity 69
- Folic Acid EP Impurity B Sulfate
- 2,4,5-Triamino-6-hydroxypyrimidine Sulfate Hydrate>
- 4(1H)-Pyrimidinone, 2,5,6-triamino-, sulfate (1:1) (9CI)
- 2,4,5-Triamino-6-hydroxypyrimidine sulfate ISO 9001：2015 REACH
- 2,4,5-Triamino-6-hydroxypyrimidine Sulfate Salt
Discontinued See: T767240 and H971250
- Folic Acid Impurity B Sulfate
- 4-hydroxy-2,5,6-triaminopyrimidine sulf. monohydr
- 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE HYDRATE
- 2,5,6-Triamino-4(1H)-pyrimidinone sulfate
- Folic Acid Impurity 26
- TAPOS
- 4(3H)-Pyrimidinone, 2,5,6-triamino-, sulfate (1:1)
- 2,5,6-triamino-4(3H)-Pyrimidinone sulfate (1:1)
- Folic Acid Impurity 2 Sulfate(Folic Acid EP Impurity B Sulfate)
- 35011-47-3
- C4H7N5OH2OH2O4S
- C4H11N5O6S
- Building Blocks
- Pyrimidines
- Heterocyclic Building Blocks
- Heterocyclic Compounds
