SULCONAZOLE

SULCONAZOLE Struktur
61318-90-9
CAS-Nr.
61318-90-9
Englisch Name:
SULCONAZOLE
Synonyma:
Sulconazol;SULCONAZOLE;SULCONAZOLE USP/EP/BP;Sulconazle Impurity 3;1-(2-((4-Chlorobenzyl);-2-(2,4-dichlorophenyl);Uniconazole sulfur nitrate;Quizalofop Impurity 8(Propaquizafop);Sulconazole (base and/or unspecified salts);1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole
CBNumber:
CB1102530
Summenformel:
C18H15Cl3N2S
Molgewicht:
397.75
MOL-Datei:
61318-90-9.mol

SULCONAZOLE Eigenschaften

Siedepunkt:
558.2±50.0 °C(Predicted)
Dichte
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
6.55±0.12(Predicted)
CAS Datenbank
61318-90-9

Sicherheit

SULCONAZOLE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.

Definition

ChEBI: A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.

Indications

Sulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.

Solubility in organics

1 part in 3,333 (water), 1 part in 100 (ethanol), 1 part in 130 (acetone), 1 part in 333 (chloroform), 1 part in 2000 (dioxan), 1 part in 71 (methanol), 1 part in 286(chloromethane), 1 part in 10 (pyridine), 1 part in 2000 (toluene).

SULCONAZOLE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SULCONAZOLE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 48)Lieferanten
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Zhejiang ZETian Fine Chemicals Co. LTD
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GIHI CHEMICALS CO.,LIMITED
+8618058761490
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+8615391658522
overseasales@yongstandards.com China 11922 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58

  • SULCONAZOLE
  • 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]- (9CI)
  • 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, (+-)-
  • 1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole
  • Uniconazole sulfur nitrate
  • 1-(2-((4-Chlorobenzyl)
  • -2-(2,4-dichlorophenyl)
  • 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
  • 1-[2-[(4-chlorophenyl)methylthio]-2-(2,4-dichlorophenyl)ethyl]-Lh-imidade
  • Sulconazole (base and/or unspecified salts)
  • Sulconazol
  • SULCONAZOLE USP/EP/BP
  • Sulconazle Impurity 3
  • Quizalofop Impurity 8(Propaquizafop)
  • 61318-90-9
  • C18H15N2Cl3S
  • C18H15Cl3N2S
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