Sodium tetraborate decahydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
WEISSE KRISTALLE ODER KRISTALLINES PULVER.
CHEMISCHE GEFAHREN
Schwache Base.
ARBEITSPLATZGRENZWERTE
TLV: (Anorganische Boratverbindungen) (Einatembare Fraktion); 2 mg/m?(als TWA); 6 mg/m?(als STEL); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf Zentralnervensystem, Nieren und Leber (beim Verschlucken). Die Auswirkungen treten u.U. verzögert ein.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen. Tierversuche zeigen, dass die Substanz möglicherweise fruchtbarkeitsschädigend oder entwicklungsschädigend wirken kann.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.
R-Sätze Betriebsanweisung:
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
White cryst. powder
Physikalische Eigenschaften
White monoclinic crystal; density 1.73 g/cm
3; decomposes at 75°C; soluble in water; the vapor pressure of the pure compound 1.6 torr at 20°C and that of a saturated solution 130 torr at 58°C; the pH of a 1% aqueous solution 9.24 (the pH is nearly independent of concentration); readily dissolves in alcohols.
Occurrence
Borax decahydrate occurs in nature as mineral, borax (tincal). It is one of the most common sodium borate ores. The compound has several industrial applications. The refined material is mostly used in household cleaning products. It is used to make pyrex and other borosilicate glasses. Borax is added to fertilizers in small quantities as a source of boron, as a trace nutrient for plants. High purity grade borax is used in cosmetics, toilet products and electrolytic capacitors. It also is used in fire retardants, adhesives and herbicides.
Verwenden
Sodium Tetraborate Decahydrate is used as a buffer in antigetn-retrieval procedure for bromodeoxyuridine immunolabeling with concurrent labeling of nuclear DNA and antigens damaged by hydrochloric acid pretreatment.
Vorbereitung Methode
Sodium borate can be prepared from minerals such as borosodium
calcite, pandermite, or tinkal; these are natural sodium or calcium
borates. Treatment of the mineral with sodium carbonate and
sodium hydrogencarbonate yields the sodium borate decahydrate.
In the USA, brine from salt lakes is also an important source of
sodium borate.
Hazard
Toxic by inhalation.
Health Hazard
Borates are irritants of the eyes,
nose, and throat; at high concentrations ingestion
of the compounds can result in gastrointestinal
irritation, kidney injury, and even death
from central nervous system depression or cardiovascular
collapse.
Pharmazeutische Anwendungen
Sodium borate is used in pharmaceutical applications similarly to
boric acid (see Boric Acid). It has been used externally as a mild
astringent and as an emulsifying agent in creams. It has also been
used in lozenges, mouthwashes, otic preparations (0.3% w/v), and
ophthalmic solutions (0.03–1.0% w/v). Sodium borate has additionally
been investigated in the prevention of crystal formation in
freeze-dried solutions.
Preparations of sodium borate in honey have historically been
used as paints for the throat, tongue, and mouth, but such use is
now inadvisable because of concerns about toxicity in such applications. Sodium borate is also used in cosmetics
such as moisturizers, deodorants, and shampoos.
Landwirtschaftliche Anwendung
Solubor is a type of borate containing 20.3% boron. It is
chemically a polyborate, similar to borax, and is
represented as Na
2B
2O
7?5H
2O +Na
2B
10O
16?10H
2O. is a
finely-ground, white product specially designed for foliar,
liquid or dust applications, to correct boron deficiency.
Sicherheitsprofil
Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. Ingestion of 5-10 g of borax by children can cause severe vomiting, diarrhea, shock, death. Incompatible with acids, metallic salts. When heated to decomposition it emits toxic fumes of Na2O, boron. See also BORON COMPOUNDS. Used in ant poisons, for fly control around refuse and manure piles, as a larvicide, in manufacture of glazes, enamels, cleaning compounds, and in soldering metals.
Sicherheit(Safety)
Sodium borate has weak bacteriostatic and astringent properties.
Historically, sodium borate has been used as a disinfectant in skin
lotions and eye-, nose-, and mouthwashes. However, boric acid is
easily absorbed via mucous membranes and damaged skin, and
severe toxicity has been observed, especially in babies and
children. Consequently, the use of sodium borate as a disinfectant
is now considered somewhat obsolete and careful use is recommended.
The toxic effects of sodium borate include vomiting,
diarrhea, erythema, CNS depression, and kidney damage. The
lethal oral intake is approximately 20 g in adults and 5 g in
children.
LD50 (guinea pig, oral): 5.33 g/kg
LD50 (mouse, IP): 2.711 g/kg
LD50 (mouse, IV): 1.320 g/kg
LD50 (mouse, oral): 2.0 g/kg
LD50 (rat, oral): 2.66 g/kg
mögliche Exposition
Borax is used as a soldering flux,
preservative against wood fungus; and as an antiseptic.
Used in ant poisons, for fly control around refuse and
manure piles, as a larvicide. It is used in the manufacture
of enamels and glazes, fiberglass insulation; sodium perborate
bleach; in tanning, cleaning compounds; for fireproofing
fabrics and wood; and in artificial aging of
wood.
Carcinogenicity
Sodium borate tested negatively in the
Ames bioassay but was found to be cytotoxic to
cultured human fibroblasts.
Lager
Sodium borate should be stored in a well-closed container in a cool,
dry, place.
Versand/Shipping
UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9—Miscellaneous
hazardous material, Technical Name Required.
läuterung methode
Crystallise the borate from water (3.3mL/g), keeping below 55o to avoid formation of the pentahydrate. Filter it off at the pump, wash it with water and equilibrate it for several days in a desiccator containing an aqueous solution saturated with respect to sucrose and NaCl. Borax can be prepared more quickly (but its water content is somewhat variable) by washing the recrystallised material at the pump with water, followed by 95% EtOH, then Et2O, and dried in air at room temperature for 12-18hours on a clock glass. [Becher in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 794-795 1963.]
Inkompatibilitäten
Dissolves in water forming a basic solution.
Boron dust may form explosive mixture with air.
Contact with strong oxidizers may be violent. Boron is
incompatible with ammonia, bromine tetrafluoride, cesium
carbide, chlorine, fluorine, interhalogens, iodic acid, lead
dioxide, nitric acid, nitric oxide, nitrosyl fluoride, nitrous
oxide, potassium nitrite, rubidium carbide, silver fluoride.
Waste disposal
Borax, dehydrated: The material
is diluted to the recommended provisional limit
(0.10 mg/L) in water. The pH is adjusted to between 6.5
and 9.1 and then the material can be discharged into sewers
or natural streams.
Regulatory Status
Accepted for use as a food additive in Europe. Included in the FDA
Inactive Ingredients Database (otic preparations; ophthalmic
solutions and suspensions). Included in nonparenteral medicines
licensed in the UK, Italy, France, Germany, and Japan. Included in
the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium tetraborate decahydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
