dolasetron
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- CAS-Nr.
- 115956-12-2
- Englisch Name:
- dolasetron
- Synonyma:
- Hsdb 7565;DOLASETRON;Dolasteron;Dorasetron;Dolasetronum;Unii-82wi2L7Q6e;dolasetron USP/EP/BP;Dolasetronum [inn-latin];Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester;3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate
- CBNumber:
- CB12130500
- Summenformel:
- C19H20N2O3
- Molgewicht:
- 324.37
- MOL-Datei:
- 115956-12-2.mol
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dolasetron Eigenschaften
- Schmelzpunkt:
- 278 ºC
- Siedepunkt:
- 535.1±50.0 °C(Predicted)
- Dichte
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
- Aggregatzustand
- Solid
- pka
- 15.36±0.30(Predicted)
- Farbe
- White
- Wasserlöslichkeit
- Soluble
- CAS Datenbank
- 115956-12-2
dolasetron Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT
3 (K
i = 20 nM). It is selective for 5-HT
3 receptors over 5-HT
1A, 5-HT
1B, 5-HT
2, dopamine D
2, α
1-, α
2-, β-adrenergic, M
1-5 muscarinic acetylcholine, and neurokinin-1 (NK
1) receptors (IC
50s = >10 μM for all). Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC
50 = 3.8 nM). It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg. Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.
Chemische Eigenschaften
White Solid
Verwenden
Dolasetron is a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist.It is used as antiemetic.
dolasetron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
dolasetron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 98)Lieferanten
115956-12-2()Verwandte Suche:
- (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate
- Dolasteron
- Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester
- 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2alpha,6alpha,8alpha,9abeta)-
- Dolasetronum
- Dolasetronum [inn-latin]
- Hsdb 7565
- Unii-82wi2L7Q6e
- (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
- 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl ester, stereoisoMer
- DOLASETRON
- 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-Indole-3-carboxylate
- 1H-Indole-3-carboxylic Acid 3-Oxooctahydro-2H-2,6-methanoquinolizin-8-yl Ester
- dolasetron USP/EP/BP
- rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
- Dorasetron
- 115956-12-2
- API
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals