tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
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- CAS-Nr.
- 869494-16-6
- Englisch Name:
- tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
- Synonyma:
- tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate;DM1Impurity14;3,6-DiazabicycL;o[3.1.1]heptane-6-carboxyL;6-Boc-3,6-diaza-bicyclo[3.1.1]heptane;6-(tert-Butyloxycarbonyl)-3,6-diazabicyclo[3.1.1]heptane;tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate 97%;3,6-Diazbiclo[.1.1]heptane-6-carboxylic acid tert-butyl ester;(1R,5S)-tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate;tert-Butyl (1S,5R)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
- CBNumber:
- CB12534807
- Summenformel:
- C10H18N2O2
- Molgewicht:
- 198.26
- MOL-Datei:
- 869494-16-6.mol
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tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate Eigenschaften
- Siedepunkt:
- 276℃
- Dichte
- 1.104
- Flammpunkt:
- 121℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 9.53±0.20(Predicted)
- Aggregatzustand
- solid
- Farbe
- White to off-white
- InChI
- InChI=1S/C10H18N2O2/c1-10(2,3)14-9(13)12-7-4-8(12)6-11-5-7/h7-8,11H,4-6H2,1-3H3
- InChIKey
- OUFBVDKNEWUFHP-UHFFFAOYSA-N
- SMILES
- C12CC(N1C(OC(C)(C)C)=O)CNC2
tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
To a stirred solution of 3,6-Diazabicyclo[3.1.1]heptane-6-carboxylic acid, 3-[(2-nitrophenyl)sulfonyl]-, 1,1-dimethylethyl ester (400 mg, 1.04 mmol) in DMF (2.5 mL) were added dodecanethiol (500 μL, 2.09 mmol) and lithium hydroxide hydrate (88 mg, 2.09 mmol). The mixture was stirred at r.t. for 2 h. The mixture was diluted with hexanes-ethyl acetate (10 mL, 1:1). The mixture was extracted with aq. Hydrochloric acid (2 x 5.0 mL). The aq. layer was extracted with hexanes-ethyl acetate (10 mL, 1:1). The combined organic layers were discarded. The aq. layer was basified with NaOH (6.0 mL of 1.0 M solution) until pH=13. The aq. layer was extracted with methylene chloride-methanol (2 x 10 mL, 9:1). The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to afford tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate as a white solid; Yield, 167 mg (81percent)
tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 167)Lieferanten
- 3,6-Diazabicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester
- 6-(tert-Butyloxycarbonyl)-3,6-diazabicyclo[3.1.1]heptane
- (1R,5S)-tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
- 3,6-Diazabicyclo[3.1.1]heptane-6-carboxylic acid, 1,1-dimethylethyl ester
- tert-Butyl (1S,5R)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
- 6-Boc-3,6-diaza-bicyclo[3.1.1]heptane
- 3,?6-?Diazabicyclo[3.1.1]?heptane-?6-?carboxylic acid, 1,?1-?dimethylethyl ester
869494-16-6
- tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate 97%
- o[3.1.1]heptane-6-carboxyL
- 3,6-DiazabicycL
- tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate
- DM1Impurity14
- 36-Diazabicyclo131.1heptan e-6-carboxylic acid tert-butyl ester
- 3,6-Diazbiclo[.1.1]heptane-6-carboxylic acid tert-butyl ester
- 869494-16-6
