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OG-L002

OG-L002 Struktur
1357302-64-7
CAS-Nr.
1357302-64-7
Englisch Name:
OG-L002
Synonyma:
CS-830;OG-L002;OG-L002 USP/EP/BP;OGL002;OG L002;OGL-002;4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-;[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o;OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
CBNumber:
CB12677399
Summenformel:
C15H15NO
Molgewicht:
225.29
MOL-Datei:
1357302-64-7.mol
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OG-L002 Eigenschaften

Siedepunkt:
416.7±45.0 °C(Predicted)
Dichte
1.193±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
insoluble in H2O; ≥22.5 mg/mL in DMSO; ≥6.82 mg/mL in EtOH
Aggregatzustand
solid
pka
9.78±0.10(Predicted)
Farbe
White to yellow
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

OG-L002 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 μM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 μM). It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes. OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.

Verwenden

OG-L002 is a novel, potent, and selective LSD1/KDM1A inhibitor that epigenetically blocks the herpes simplex lytic replication and reactivation from latency.

OG-L002 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

OG-L002 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 98)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 24330 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811783
sales@trio-pharmatech.com (International market) China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
 sales@meilune.com China 4668 58
  • OG-L002
  • [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o
  • OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
  • OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
  • 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol
  • 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
  • OGL002;OG L002;OGL-002
  • CS-830
  • [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
  • OG-L002 USP/EP/BP
  • 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
  • 1357302-64-7
  • Inhibitors
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