RO-31-7549

125313-65-7

CAS-Nr.: 125313-65-7

Englisch Name:: RO-31-7549

Synonyma:: RO-31-7549;RO 31-7549 ACETATE SALT;Bisindolylmaleimide VIII;BISINDOLYLMALEIMIDE VIII ACETATE;BIDINDOLYLMALEIMIDE VIII, ACETETE;Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-

CBNumber:: CB1281637

Summenformel:: C24H22N4O2

Molgewicht:: 398.46

MOL-Datei:: 125313-65-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 39

RO-31-7549 Eigenschaften

storage temp.: −20°C

Löslichkeit: DMSO: soluble

Aggregatzustand: Red to reddish-orange solid

Sicherheit

WGK Germany	3

RO-31-7549 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

It is a potent inhibitor of protein kinase C (PKC) activity.

Allgemeine Beschreibung

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ₁. Exhibits some degree of PKC isozyme specificity (IC₅₀ = 53 nM for PKC_α, 195 nM for PKC_βI, 163 nM for PKC_βII, 213 nM for PKC_γ, and 175 nM for PKC_ε). Inhibits carbachol-evoked noradrenaline release (IC₅₀ = 600 nM).

Biochem/physiol Actions

Cell permeable: yes

RO-31-7549 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RO-31-7549 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 39)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	56068	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

BISINDOLYLMALEIMIDE VIII ACETATE
1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Bisindolylmaleimide VIII
2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE
RO-31-7549
RO 31-7549 ACETATE SALT
BIDINDOLYLMALEIMIDE VIII, ACETETE
Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
125313-65-7
C24H22N4O2C2H4O2
Amines
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Protein Kinase Inhibitors and Activators