Tenofovir alafenamide hemifumarate
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- CAS-Nr.
- 1392275-56-7
- Englisch Name:
- Tenofovir alafenamide hemifumarate
- Synonyma:
- Tenofovir Alafenamide fumarate;GS7340(Tenofovir Alafenamide Fumarate);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);Anti-HIV;API-Anti-HBV;Tenofovir Alafenamid;GS-7340 (hemifumarate);Alafenamide hemifumarate;Tenofovir levamide amine fumarate
- CBNumber:
- CB13038481
- Summenformel:
- C25H33N6O9P
- Molgewicht:
- 592.55
- MOL-Datei:
- 1392275-56-7.mol
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Tenofovir alafenamide hemifumarate Eigenschaften
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- CAS Datenbank
- 1392275-56-7
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Tenofovir alafenamide hemifumarate Chemische Eigenschaften,Einsatz,Produktion Methoden
Definition
ChEBI: Tenofovir alafenamide fumarate is a fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a prodrug. It contains a tenofovir alafenamide(1+).
Arzneimittelwechselwirkung
Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).
Advantages
One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.
Tenofovir alafenamide hemifumarate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tenofovir alafenamide hemifumarate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 321)Lieferanten
- L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)
- N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1)
- GS-7340 (hemifumarate)
- TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
- Tenofovir levamide amine fumarate
- GS7340(Tenofovir Alafenamide Fumarate)
- (Tenofovir alafenamide : fumarate = 2:1)
- Anti-HIV
- API-Anti-HBV
- (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1)
- (R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate
- N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
- (S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate
- Tenofovir Alafenamide fumarate [USAN]
- Alafenamide hemifumarate
- Tenofovir Alafenamide Hemifumarate(2:1)
- Tenofovir Alafenamide Fumarate USP/EP/BP
- Tenofovir Alafenamid
- Tenofovir Alafenamide Hemifumarate salt[USAN
- Tenofovir alafenamide hemifumarate
- Tenofovir alafenamide hemifumarate (GS-7340)
- Tenofovir Alafenamide Hemifumarate salt
- Tenofovir Alafenamide fumarateQ: What is
Tenofovir Alafenamide fumarate Q: What is the CAS Number of
Tenofovir Alafenamide fumarate
- 3H-1,2,4-Triazole-3-thione,4-amino-2,4-dihydro-5-(10-methoxyphenyl)-
- Tenofovir Alafenamide fumarate
- Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate
- Tenofovir dipivoxil phenol amine fumarate
- 2-fluoro-5-[(4' -0x0-3'H-phthalazin-1'-yl)methyllbenzoic acide'
- Tenofovir Alafenamide Hemifumarate(2:1) CRS
- Tenofovir Alafenamide Fumarate API
- GS-7340 (hemifumarate)|||Tenofovir alafenamide fumarate
- Celiprolol Impurity 8(Celiprolol EP Impurity H)
- 1392275-56-7
- C46H62N12O14P2
- 2C21H29N6O5PC4H4O4
- API
- 1392275-56-7
