CCF-642
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- CAS-Nr.
- 346640-08-2
- Englisch Name:
- CCF-642
- Synonyma:
- CCF-642;AC1LYELL;CCF 642, ≥98%;CCF 642;CCF-642;CCF642 >=98% (HPLC);CCF 642;CCF-642;AC1LYELL;3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-;3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one;calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
- CBNumber:
- CB13133223
- Summenformel:
- C15H10N2O4S3
- Molgewicht:
- 378.45
- MOL-Datei:
- 346640-08-2.mol
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CCF-642 Eigenschaften
- Siedepunkt:
- 567.3±60.0 °C(Predicted)
- Dichte
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO:14.4(Max Conc. mg/mL);38.05(Max Conc. mM)
- pka
- -0.70±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow to orange
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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CCF-642 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CCF642 has been used as a protein disulfide isomerase (PDI) inhibitor to study its ability to reduce the expression of endoplasmic reticulum (ER) stress markers and neuroinflammation in the hippocampus of experimental autoimmune encephalomyelitis (EAE) mice.
Biochem/physiol Actions
CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs instead of cysteine known to be targeted by PACMA 31. CCF642 displays anti-multiple myeloma (MM) activity both in cultures in vitro (IC50 <1 μM against murine 5TGM1 and nine human MM lines) and in mice in vivo (10 mg/kg, 3X i.p. per wk) without apparent adverse effects to the animals or being cytotoxic to normal bone marrow (NLBM) cells even at concentrations as high as 6.75 μM. Consistent with PDI′s role in ER protein folding process, CCF642 treatment causes acute ER stress accompanied by apoptosis-inducing calcium release in MM cells.
CCF-642 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CCF-642 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 66)Lieferanten
346640-08-2()Verwandte Suche:
- CCF-642
- 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
- CCF 642;CCF-642
- AC1LYELL
- CCF 642;CCF-642;AC1LYELL
- 4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-
- CCF642 >=98% (HPLC)
- CCF 642, ≥98%
- 3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one
- calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
- 346640-08-2
