2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

6318-41-8

CAS-Nr.: 6318-41-8

Englisch Name:: 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

Synonyma:: PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K

CBNumber:: CB13232856

Summenformel:: C11H7NO4S

Molgewicht:: 249.24

MOL-Datei:: 6318-41-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 22

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Eigenschaften

Dichte: 1.595±0.06 g/cm3(Predicted)

storage temp.: +2C to +8C

Löslichkeit: Soluble in DMSO (up to 25 mg/ml).

Aggregatzustand: Yellow solid

pka: 7.13±0.20(Predicted)

Farbe: Yellow

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC₅₀ = 70 nM), compared to PI3Kα (IC₅₀ = 240 nM), PI3Kβ (IC₅₀ = 1.45 μM), and PI3Kδ (IC₅₀ =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED₅₀ = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 22)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3552	55
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9854	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	29778	58
InvivoChem	13549236410	sales@invivochem.cn	China	6749	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

6318-41-8()Verwandte Suche:

Oxaprozin Rolipram 3-Methyl-3H-adenin

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
6318-41-8