Cefditoren Pivoxil Dimer

Cefditoren Pivoxil Dimer Struktur
CAS-Nr.
Englisch Name:
Cefditoren Pivoxil Dimer
Synonyma:
Cefditoren Pivoxil Dimer
CBNumber:
CB13370116
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Cefditoren Pivoxil Dimer Eigenschaften

Sicherheit

Cefditoren Pivoxil Dimer Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(E)-Cefditoren Pivoxil Dimer is derivative of Cefditoren Pivoxil. Cefditoren Pivoxil is an antibacterial. Third generation cephalosporin.

synthetische

The preparation (scheme 1) starts from Cefditoren pivoxil (24.83g, 0.04mol), formalin (3.48g, mass fraction are 37%~40%) and sulfuric acid (0.12g, 1.2mmol), which is added in acetonitrile (125mL), and keeping the temperature 80℃ for 2.0h, then the reaction solution is cooled down to room temperature. The solution is added the mixture of purified water (100mL) and ethyl acetate (200mL) and keep stirring 10min after liquid separation. After being filtered, purified and recrystallized, the finished dimer was got with yield 87.6%.
1.jpg
Scheme 1 The synthesis of Cefditoren Pivoxil Dimer
Zhangying and his coworkers developed another method to cefditoren pivoxil dimer.
2.jpg
Scheme 2 The synthesis of Cefditoren Pivoxil Dimer
Scheme 2 shows the reaction mechanism. First, the cephem compounds (1) nucleophilic attack of the amino Vilsmeier reagent (1), to generate intermediate (3); another molecule cephem compound (I) followed by nucleophilic attack of the amino group resulting intermediate (3) to generate intermediate (5); and then the intermediate (5) dimethylamine off, to form the intermediate (6), the generates the desired products (7) by the transfer of hydrogen ions.

Cefditoren Pivoxil Dimer Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cefditoren Pivoxil Dimer Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Guangzhou PI PI Biotech Inc +86-020-81716320 +86-13602409664
Sales@pipitech.com China 3635 55
Guangzhou Longying Biotechnology Co., Ltd. 15975567350 15975567350
loninbio@sohu.com China 476 58
PI & PI BIOTECH INC. 020-81716320 17788709170
Sales@pipitech.com China 2649 58
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd 18102736234 18102736234
2208093734@qq.com China 7256 58

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