Prasugrel-d5 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Prasugrel-d
5 is intended for use as an internal standard for the quantification of prasugrel by GC- or LC-MS. Prasugrel is a prodrug form of the platelet purinergic P2Y
12 receptor antagonist R-99224. Prasugrel (0.3 and 3 mg/kg) inhibits
ex vivo washed platelet aggregation in rat platelet rich-plasma.
In vivo, prasugrel prevents thrombus formation (ED
50 = 0.68 mg/kg) and increases tail bleeding time in rats. Formulations containing prasugrel have been used in the prevention of blood clots.
Verwenden
A novel labelled antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome
Prasugrel-d5 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
