3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
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- CAS-Nr.
- 622387-85-3
- Englisch Name:
- 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
- Synonyma:
- OXSI 2;Syk Inhibitor;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
- CBNumber:
- CB1364747
- Summenformel:
- C18H15N3O3S
- Molgewicht:
- 353.39
- MOL-Datei:
- 622387-85-3.mol
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3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Eigenschaften
- storage temp.
- Store at -20°C
- Löslichkeit
- Soluble in DMSO
- Aggregatzustand
- Orange powder solid.
- Farbe
- Light yellow to brown
- Sensitive
- Light Sensitive
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Spleen tyrosine kinase (Syk) is a non-
receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-
based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC
50 value of 14 nM and inhibits FcεRI-
mediated rat RBL-
2H3 basophil cell degranulation (EC
50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-
induced platelet aggregation and shape change.
Verwenden
OXSI 2 is a Syk selective inhibitor.
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 38)Lieferanten
- Syk Inhibitor
- 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
- OXSI 2
- 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
- 3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE
- 1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-
- Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
- 622387-85-3
- C18H15N3O3S
- pharmacetical
- Spleen Tyrosine Kinase Inhibitor