HS-10296

1899921-05-1

CAS-Nr.: 1899921-05-1

Englisch Name:: HS-10296

Synonyma:: HS-10296;Almonertinib;HS 10296;HS10296;2H6]-Almonertinib;Almonertinib (HS-10296);HS-10296;HS 10296;HS10296;1899921-05-1;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-;inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC

CBNumber:: CB14808621

Summenformel:: C30H35N7O2

Molgewicht:: 525.66

MOL-Datei:: 1899921-05-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 54

HS-10296 Eigenschaften

Dichte: 1.24±0.1 g/cm3(Predicted)

Löslichkeit: DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM)

pka: 12.68±0.70(Predicted)

Aggregatzustand: Solid

Farbe: Off-white to light yellow

Sicherheit

HS-10296 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

HS-10296 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

HS-10296 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 54)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10978	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

HS-10296
N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide
HS-10296;HS 10296;HS10296;1899921-05-1
HS 10296;HS10296
Almonertinib (HS-10296)
Almonertinib
2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
2H6]-Almonertinib
inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC
1899921-05-1
C30H35N7O2