NSC 663284
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- CAS-Nr.
- 383907-43-5
- Englisch Name:
- NSC 663284
- Synonyma:
- NSC 663284 (DA3003-1);CDC25 Phosphatase Inhibitor II, NSC 663284;5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-;CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
- CBNumber:
- CB1504040
- Summenformel:
- C15H16ClN3O3
- Molgewicht:
- 321.76
- MOL-Datei:
- 383907-43-5.mol
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NSC 663284 Eigenschaften
- Siedepunkt:
- 478.8±45.0 °C(Predicted)
- Dichte
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: 16 mg/mL
- Aggregatzustand
- solid
- pka
- 6.79±0.10(Predicted)
- Farbe
- red
- Sensitive
- Light Sensitive
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
NSC 663284 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
CDC25 Phosphatase Inhibitor II, NSC 663284 is a competitive CDC25 inhibitor and cell cycle arresting compound.
Allgemeine Beschreibung
A cell-permable, potent, irreversible, and competitive inhibitor of the Cdc25 phosphatase family (K
i = 29 nM, 95 nM, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively) with anti-proliferative properties. Displays nearly 20- and 450-fold greater selectivity over VHR and PTP1B (IC
50 = 4.0 μM and >100 μM, respectively). Reported to arrest cell cycle progression, inhibit Cdk dephosphorylation, and delay tumor growth (mean IC
50 = 1.5 μM in NCI-60 tumor cell panel). Also shown to block ERK dephosphorylation caused by ectopic Cdc25A expression.
Biologische Aktivität
Potent, selective inhibitor of Cdc25 dual specificity phosphatases (K i values are 29, 95 and 89 nM for human Cdc25A, Cdc25B 2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G 1 and G 2 /M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC 50 = 0.2-35 μ M).
NSC 663284 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NSC 663284 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 44)Lieferanten
- CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
- 5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-
- CDC25 Phosphatase Inhibitor II, NSC 663284
- NSC 663284 (DA3003-1)
- 383907-43-5
- Protein Phosphatase
