ANTI-GM130 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-GM130 (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- indirect immunofluorescence
- immunoprecipitation
- immunohistochemistry
Allgemeine Beschreibung
Golgi Matrix Protein of 130 kDa (GM130) is a peripheral cytoplasmic protein and is a member of the golgin family of Golgi autoantigens. GM130 is an extended rod-like protein containing coiled-coil domains and is tightly bound to Golgi membranes.
Biochem/physiol Actions
Golgi Matrix Protein of 130 kDa (GM130) is involved in maintaining the structural integrity of the Golgi apparatus and vesicular transport. GM130 also interacts with Golgi reassembly-stacking protein of 65 kDa (GRASP65) and participated in postmitotic reassembly and stacking of the Golgi cisternae. The protein along with p115 and GRASP65 might acts as a template in nucleating the formation of the Golgi apparatus. GM130 in complex with GRASP65 and other proteins interacts with activated Rab1, a protein known to regulate the transport of newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. This antibody can be used as a cis-Golgi network marker.
ANTI-GM130 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
