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HYDROXYFASUDIL MONOHYDROCHLORIDE

HYDROXYFASUDIL MONOHYDROCHLORIDE Struktur
155558-32-0
CAS-Nr.
155558-32-0
Englisch Name:
HYDROXYFASUDIL MONOHYDROCHLORIDE
Synonyma:
Fasudil Hydroxy;Hydroxyfasudil HCl;Fasudil Impurity 7 HCl;Hydroxyfasudil (HA-1100);Hydroxyfasudil HCl (HA1100);Hydroxyfasudil Hydrochloride;Hydroxyfasudil (HA-1100) HCl;HYDROXYFASUDIL MONOHYDROCHLORIDE;Hydroxyfasudil hydrochloride hydrate;HA 1100 hydrochloride (Hydroxyfasudil)
CBNumber:
CB1973040
Summenformel:
C14H18ClN3O3S
Molgewicht:
343.82902
MOL-Datei:
155558-32-0.mol
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HYDROXYFASUDIL MONOHYDROCHLORIDE Eigenschaften

Schmelzpunkt:
>250 (dec.)
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
H2O: >5mg/mL
Aggregatzustand
solid
Farbe
white
Wasserlöslichkeit
Soluble in water (20mM)
InChIKey
XWWFOUVDVJGNNG-UHFFFAOYSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

HYDROXYFASUDIL MONOHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

Chemische Eigenschaften

Off-White Solid

Allgemeine Beschreibung

A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.

HYDROXYFASUDIL MONOHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

HYDROXYFASUDIL MONOHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 98)Lieferanten
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155558-32-0()Verwandte Suche:

Chinolin-5-sulfonsure 8-Methylchinolin Chinolin Isochinolin Chinaldin Chinolin-8-sulfonsure 1,3-Dibrompropan 2-Methylnaphthalin 1-Methyl-naphthalin
  • 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
  • Hydroxyfasudil Hydrochloride
  • 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride
  • HYDROXYFASUDIL MONOHYDROCHLORIDE
  • Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
  • 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
  • Hydroxyfasudil hydrochloride hydrate
  • Hydroxyfasudil (HA-1100)
  • HA-1100 HYDROCHLORIDE;HA 1100 HYDROCHLORIDE;HA1100 HYDROCHLORIDE
  • 5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one
  • Hydroxyfasudil hydrochloride (HA-1100 hydrochloride)
  • Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
  • Hydroxyfasudil HCl
  • Hydroxyfasudil (HA-1100) HCl
  • 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
  • Fasudil Impurity 7 HCl
  • Fasudil Hydroxy
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride
  • 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
  • Hydroxyfasudil HCl (HA1100)
  • 5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one,hydrochloride
  • HA-1100,ROCK,Hydroxyfasudil Hydrochloride,Hydroxyfasudil,Rho-associated kinase,HA 1100,inhibit,HA1100,Rho-kinase,Rho-associated protein kinase,ROK,Inhibitor
  • Hydroxyfasudil hydrochloride hydrate Hydroxyfasudil hydrochloride
  • HA 1100 hydrochloride (Hydroxyfasudil)
  • 155558-32-0
  • C14H17N3O3SHCl
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
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