(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
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- CAS-Nr.
- 1062580-52-2
- Englisch Name:
- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- Synonyma:
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
- CBNumber:
- CB21011155
- Summenformel:
- C14H23ClN2
- Molgewicht:
- 254.8
- MOL-Datei:
- Mol file
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Eigenschaften
- Schmelzpunkt:
- 249~251℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
- InChIKey
- FVRZQLQXDPJADE-WLZBWWFYNA-N
- SMILES
- C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
HazardClass |
IRRITANT |
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HS Code |
2933399990 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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Sicherheit |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
P330 |
Mund ausspülen. |
P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthese
![Synthesis_1062580-52-2](/NewsImg/2021-12-27/6377621733007887364937435.jpg)
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 362)Lieferanten
Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
Changsha Junyu Chemexpress.co., Ltd
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+86-13723890100
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info@csjyyy.cn |
China |
134 |
58 |
Shanghai Boc Chemical Co., Ltd.
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021-34975602; +8618721111801
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shangli@bocchem.com |
China |
138 |
58 |
Purest Pharmaceuticl (Xi’an) Co,.LTD
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+8613893405577
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12829054@qq.com |
China |
74 |
58 |
Hangzhou ICH Biofarm Co., Ltd
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+86-0571-28186870; +undefined8613073685410
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sales@ichemie.com |
China |
988 |
58 |
hebei hongtan Biotechnology Co., Ltd
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+86-86-1913198-3935 +8617331935328
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sales03@chemcn.cn |
China |
973 |
58 |
Capot Chemical Co.,Ltd.
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571-85586718 +8613336195806
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sales@capotchem.com |
China |
29798 |
60 |
Beijing Cooperate Pharmaceutical Co.,Ltd
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010-60279497
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sales01@cooperate-pharm.com |
CHINA |
1811 |
55 |
Henan Tianfu Chemical Co.,Ltd.
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+86-0371-55170693 +86-19937530512
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info@tianfuchem.com |
China |
21668 |
55 |
Hangzhou FandaChem Co.,Ltd.
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008657128800458; +8615858145714
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fandachem@gmail.com |
China |
9332 |
55 |
Nanjing ChemLin Chemical Industry Co., Ltd.
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025-83697070
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product@chemlin.com.cn |
CHINA |
3012 |
60 |
- CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)
- cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%
- cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE
- (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE)
- 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-
- (3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi
- (3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine
- Tofacitinib interMediate A
- (3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID
- 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)-
- Tofacitinib intermediate 3
- (3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride
- Azilsartan medoxomil impurity351
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro...
- Tofacitinib Impurity 5 Dihydrochloride
- N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE
- Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl )
- (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride
- piperidin-3-amine dihydrochL
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2)
- Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride
- Tofacitinib-1
- TOF30
- (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
- (3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride
- Tofatinib Impurity 5
- (3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride
- CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib (Int.)
- Tofacitinib Impurity 123 DiHCl
- (3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl
- (3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride
- 1062580-52-2
- C14H22N22HCl
- 1