ANTI-C33 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-RRM2 antibody produced in mouse has been used in:
- immunohistochemistry
- western blotting
- immunofluorescence
Allgemeine Beschreibung
The ribonucleotide reductase regulatory subunit M2 (RRM2) gene is located on the human chromosome at 2p25.1. RRM2 protein is a component of ribonucleotide reductase (RR). This protein is a dimer and each dimer consists of tyrosine?free-radical and non-heme iron.
Biochem/physiol Actions
Ribonucleotide reductase regulatory subunit M2 (RRM2) protein regulates the activity of ribonucleotide reductase (RR) during the G1/early S phase of the cell cycle when DNA replication takes place. This protein provides the essential precursors for DNA synthesis. RRM2 protein catalyzes the biogenesis of deoxyribonucleotides from their corresponding ribonucleotides. RRM2 protein acts as a biomarker for various human cancers. Overexpression of RRM2 gene is observed during tumor progression, cellular response to DNA damage and increased cellular invasiveness.
ANTI-C33 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
