4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide

1032229-33-6

CAS-Nr.: 1032229-33-6

Englisch Name:: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide

Synonyma:: A939572;SCD inhibitor;A939572;A-939572;A 939572;SCD1 Inhibitor (DMSO solution);stearoyl-CoA desaturase (SCD) inhibitor;4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide;4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)-phenyl)piperidine-1-carboxamide (A939572)

CBNumber:: CB22473855

Summenformel:: C20H22ClN3O3

Molgewicht:: 387.86

MOL-Datei:: 1032229-33-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 92

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Eigenschaften

Siedepunkt:: 633.5±55.0 °C(Predicted)

Dichte: 1.302±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: insoluble in H2O; ≥17.15 mg/mL in DMSO; ≥2.5 mg/mL in EtOH with ultrasonic

Aggregatzustand: solid

pka: 13.65±0.70(Predicted)

Farbe: White to off-white

Sicherheit

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide is a stearoyl-CoA desaturase 1 (SCD1) inhibitor.

Biologische Aktivität

A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

Einzelnachweise

[1] xin z, zhao h, serby m d, et al. discovery of piperidine-aryl urea-based stearoyl-coa desaturase 1 inhibitors. bioorganic & medicinal chemistry letters, 2008, 18(15): 4298-4302.
[2] Low glycaemic diets alter lipid metabolism to influence tumour growth Authors: Lien Et al. Nature 2021;599:302.

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 92)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Suzhou Laing Biotechnology Co.,Ltd	+86-13004516015 +86-18149392822	christina@laingbiotec.com	China	778	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32835	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49403	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29820	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Suzhou Victorypharm Co.,Ltd.	+86-13916956214	sales@victory-pharm.com	China	1301	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

SCD inhibitor
stearoyl-CoA desaturase (SCD) inhibitor
A939572
4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide
A939572;A-939572;A 939572
4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)-phenyl)piperidine-1-carboxamide (A939572)
SCD1 Inhibitor (DMSO solution)
1032229-33-6