3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
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- CAS-Nr.
- 629664-81-9
- Englisch Name:
- 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
- Synonyma:
- XL335;CS-899;Fxr 450;Way 362450;Unii-S6kdm312I5;WAY-362450 (XL335;Turofexorate isopropyl;WAY-362450 >=98% (HPLC);WAY362450 - FXR450 - XL335;XL335;TUROFEXORATE ISOPROPYL
- CBNumber:
- CB22484921
- Summenformel:
- C25H24F2N2O3
- Molgewicht:
- 438.47
- MOL-Datei:
- 629664-81-9.mol
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3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Eigenschaften
- Siedepunkt:
- 617.3±55.0 °C(Predicted)
- Dichte
- 1.275
- storage temp.
- room temp
- Löslichkeit
- DMSO : 25 mg/mL (57.02 mM; Need ultrasonic)
- Aggregatzustand
- powder
- pka
- 16.49±0.60(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Biochem/physiol Actions
WAY-362450 is a potent and selective Farnesoid X receptor (FXR) agonist that lowers total plasma cholesterol (all lipoprotein species). WAY-362450 reduced the levels of high-density lipoprotein cholesterol (HDLc) in Cynomolgus monkeys, mice and hamsters. Apparently HDL lowering is achieved through increased transhepatic cholesterol efflux.
3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 110)Lieferanten
- 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
- Fxr 450
- Turofexorate isopropyl
- Turofexorate isopropyl [usan]
- Unii-S6kdm312I5
- Way 362450
- isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
- isopropyl 3-(3,4-difluorobenzoyl)-1,1-diMethyl-1,2,3,6-tetrahydr
- WAY362450 - FXR450 - XL335
- XL335
- Isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxyla
- (E)-isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate
- Turofexorate Isopropyl (XL335)
- propan-2-yl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-2,6-dihydroazepino[4,5-b]indole-5-carboxylate
- WAY-362450 (XL335
- Isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carbox
- isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,4,5,5a,6,10b-octahydroazepino[4,5-b]indole-5-carboxylate
- XL335;TUROFEXORATE ISOPROPYL
- CS-899
- XL335; WAY 362450; TUROFEXORATE ISOPROPYL; WAY-362450
- Azepino[4,5-b]indole-5-carboxylic acid, 3-(3,4-difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethyl-, 1-methylethyl ester
- WAY-362450 >=98% (HPLC)
- Turofexorate isopropyl XL335 XL-335 WAY-362450 WAY362450
- 629664-81-9
- Inhibitors
- A farnesoid X receptor (FXR) agonist .