JGB1741

1256375-38-8

CAS-Nr.: 1256375-38-8

Englisch Name:: JGB1741

Synonyma:: JGB1741;CRTIXRJWHKMWCH-STBIYBPSSA-N;Benzo[b]thiophene-3-carboxamide, 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-

CBNumber:: CB22591386

Summenformel:: C27H24N2O2S

Molgewicht:: 440.56

MOL-Datei:: 1256375-38-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 24

JGB1741 Eigenschaften

Schmelzpunkt:: 242-243 °C

Siedepunkt:: 700.2±60.0 °C(Predicted)

Dichte: 1.28±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: ≤0.2mg/ml in DMSO;0.14mg/ml in dimethyl formamide

Aggregatzustand: crystalline solid

pka: 8.00±0.50(Predicted)

Farbe: Light yellow to yellow

Sicherheit

JGB1741 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The sirtuins (SIRTs) are a family of NAD⁺-dependent histone deacetylases involved in gene regulation that is relevant to longevity, cancer, gene regulation, energy homeostasis, and apoptosis. JGB1741 is a small molecule inhibitor of SIRT1 with an IC₅₀ value of 15 μM in a cell-free assay. It shows relatively weak inhibition for SIRT2 and SIRT3 with IC₅₀ values greater than 100 μM. JGB1741 inhibits metastatic breast cancer MDA-MB 231 cell proliferation with an IC₅₀ value of 512 nM in a cell-based assay and dose-dependently increases p53 acetylation and p53-mediated apoptosis in these cells.

JGB1741 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

JGB1741 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 24)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	384	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9274	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

JGB1741
Benzo[b]thiophene-3-carboxamide, 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-
CRTIXRJWHKMWCH-STBIYBPSSA-N
1256375-38-8