SB-705498

501951-42-4

CAS-Nr.: 501951-42-4

Englisch Name:: SB-705498

Synonyma:: CS-279;SB-705498;SB 705498;SB705498;1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]urea;(R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea;N-(2-Bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]urea;Urea, N-(2-bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]-

CBNumber:: CB22628383

Summenformel:: C17H16BrF3N4O

Molgewicht:: 429.23

MOL-Datei:: 501951-42-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 102

SB-705498 Eigenschaften

Siedepunkt:: 506.9±50.0 °C(Predicted)

Dichte: 1.59

storage temp.: -20°C

Löslichkeit: Soluble in DMSO (>25 mg/ml)

pka: 13.00±0.20(Predicted)

Aggregatzustand: solid

Farbe: White

Stabilität:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

SB-705498 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin . SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pK_is = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively). It has been shown to induce rapid, reversible inhibition of capsaicin (IC₅₀ = 3 nM)-, acid (pH 5.3)-, or heat (50°C; IC₅₀ = 6 nM)-mediated activation of human TRPV1 (at -70 mV).

SB-705498 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SB-705498 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 102)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	4087	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32072	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38466	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19632	58

SB-705498
N-(2-Bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]urea
(R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea
1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]urea
CS-279
SB 705498;SB705498
Urea, N-(2-bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]-
501951-42-4
C17H16BrF3N4O
Inhibitors