Methyl 4-ketocyclohexanecarboxylate
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- CAS-Nr.
- 6297-22-9
- Englisch Name:
- Methyl 4-ketocyclohexanecarboxylate
- Synonyma:
- 4-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER;NSC 17321;4-carbomethoxycyclohexanone;4-(Methoxycarbonyl)cyclohexanone;Methyl 4-cyclohexanonecarboxylate;methyl 4-oxocyclohexancarboxylate;Methyl cyclohexanone-4-carboxylate;METHYL 4-KETOCYCLOHEXANECARBOXYLATE;4-CYCLOHEXANE CARBOXYLIC ACID METHYL ESTER;4-Oxocyclohexane-1-carboxylic acid methyl ester
- CBNumber:
- CB2282868
- Summenformel:
- C8H12O3
- Molgewicht:
- 156.18
- MOL-Datei:
- 6297-22-9.mol
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Methyl 4-ketocyclohexanecarboxylate Eigenschaften
- Siedepunkt:
- 96-97 °C(Press: 8.0 Torr)
- Dichte
- 1.11g/ml
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- soluble in Chloroform, Methanol
- Aggregatzustand
- Oil
- Farbe
- Clear Colourless
- InChI
- InChI=1S/C8H12O3/c1-11-8(10)6-2-4-7(9)5-3-6/h6H,2-5H2,1H3
- InChIKey
- BLYKGTCYDJZLFB-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)CCC(=O)CC1
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H227 |
Combustible liquid |
Flammable liquids |
Category 4 |
Warnung |
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P210, P280, P370+P378, P403+P235,P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Methyl 4-ketocyclohexanecarboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Methyl 4-Oxocyclohexanecarboxylate is an intermediate for preparation of imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for treatment of sleep disorders.
Synthese
The 4-hydroxy methyl ester (4.147 g; 26.21 mmol) was dissolved in 150 mL DCM, and pyridinium chlorochromate (PCC) (8.476 g; 39.32 mmol) was added. The reaction mixture was allowed to stir at room temperature overnight. The reaction mixture was diluted with ether and decanted. Solvents were removed, and the residue was purified by flash column chromatography using 25 percent EtOAc in a hexane mixture as eluent. The product Methyl 4-ketocyclohexanecarboxylate was obtained as a colorless oil.
Methyl 4-ketocyclohexanecarboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl 4-ketocyclohexanecarboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 149)Lieferanten
6297-22-9()Verwandte Suche:
- METHYL 4-KETOCYCLOHEXANECARBOXYLATE
- Cyclohexanecarboxylic acid, 4-oxo-, methyl ester
- methyl 4-oxocyclohexancarboxylate
- 4-Oxocyclohexane-1-carboxylic acid methyl ester
- 4-CYCLOHEXANE CARBOXYLIC ACID METHYL ESTER
- Methyl cyclohexanone-4-carboxylate
- 4-(Methoxycarbonyl)cyclohexanone
- NSC 17321
- Methyl 4-cyclohexanonecarboxylate
- 4-carbomethoxycyclohexanone
- 4-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER
- Cyclohexanecarboxylic acid, 4-oxo-, methyl este
- 6297-22-9
- Drug Intermediates
- Intermediates
- Miscellaneous Reagents
