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Mirogabalin

Mirogabalin Struktur
1138245-13-2
CAS-Nr.
1138245-13-2
Englisch Name:
Mirogabalin
Synonyma:
Asapiprant;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid;DS5565;A200-0700;Milobarin;mirobalin;Miluobalin;Mirogabalin;Mirogabalin HCl;DS5565;A200-0700
CBNumber:
CB23051612
Summenformel:
C12H19NO2
Molgewicht:
209.28
MOL-Datei:
1138245-13-2.mol
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Mirogabalin Eigenschaften

Siedepunkt:
357.5±15.0 °C(Predicted)
Dichte
1.104±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMF:0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Ethanol:1.25(Max Conc. mg/mL);5.97(Max Conc. mM)
PBS (pH 7.2):0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Water:5.36(Max Conc. mg/mL);25.61(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
4.65±0.10(Predicted)
Farbe
Light yellow to light brown
InChI
InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
InChIKey
FTBQORVNHOIASH-CKYFFXLPSA-N
SMILES
[C@]12([H])[C@]([H])([C@@](CN)(CC(O)=O)C1)C=C(CC)C2
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Mirogabalin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α2δ-1 and α2δ-2 subunits of voltage-dependent Ca2+ channels. Mirogabalin has potent and sustained analgesic effects (ED50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID50 = 9.4 mg/kg) or locomotor activity (ID50 = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.

Verwenden

Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.

Trademarks

Mirogabalin (brand name Tarlige; developmental code name DS-5565) is a gabapentinoid medication developed by Daiichi Sankyo.

Mirogabalin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Mirogabalin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 182)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Beijing Hope Pharmaceutical Co., Ltd.
+86-010-67886402 +8613611125266
 market@hopelife.cn China 71 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32760 60
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Hebei Yanxi Chemical Co., Ltd. 		+86-17531190177; +8617531190177
 peter@yan-xi.com China 6011 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551
info@afinechem.com China 15395 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9624 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
Joyochem Co.,Ltd 		+86-0531-82687558 +8613290333633
 sales@joyochem.com China 41 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
  • Mirogabalin
  • [(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
  • A200-0700
  • DS5565;A200-0700
  • 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid
  • MIROGABALIN; DS-5565
  • DS 5565;DS-5565;DS5565
  • Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-
  • Miluobalin
  • 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid
  • Asapiprant
  • DS5565
  • Mirogabalin HCl
  • Milobarin
  • Mirogabalin Impurity
  • mirobalin
  • Mirogabalin free base
  • 1138245-13-2
  • API
  • 1138245-13-2
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