Nefiracetam
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- CAS-Nr.
- 77191-36-7
- Englisch Name:
- Nefiracetam
- Synonyma:
- DMMPA;dmppa;dm9384;DZL-221;Translon;NEFIRACETAM;Nefiracetam>Nefiracetam powder;Nefiracetam (DM9384;Racetam Nefiracetam
- CBNumber:
- CB2416333
- Summenformel:
- C14H18N2O2
- Molgewicht:
- 246.3
- MOL-Datei:
- 77191-36-7.mol
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Nefiracetam Eigenschaften
- Schmelzpunkt:
- 151-155°C
- Siedepunkt:
- 458.5±33.0 °C(Predicted)
- Dichte
- 1.187±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO: >5mg/mL
- pka
- 13.77±0.70(Predicted)
- Aggregatzustand
- solid
- Farbe
- white to off-white
- Merck
- 14,6439
- InChI
- InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
- InChIKey
- NGHTXZCKLWZPGK-UHFFFAOYSA-N
- SMILES
- N1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O
- CAS Datenbank
- 77191-36-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UX9655650 |
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| HS Code |
2933.79.1500 |
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| Toxizität |
LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Nefiracetam Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Verwenden
Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.
Biologische Aktivität
Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .
Mechanism of action
The mechanisms of nefiracetam seem to be linked back to two pathways. One of these pathways prolongs the opening of calcium channels (tied into PKA and a Gi/o protein), which enhances the signalling of a receptor independent of the synapse. The other pathway seems to be tied into PKC and CAMKII, which then augments signalling through cholinergic receptors (which then releases most excitatory neurotransmitters from the presynaptic level, like nicotine). The former pathway (calcium channels) appears critical for long-term potentiation, whereas the latter pathway (PKC/CAMKII) appears vital for neuronal signal enhancement. Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.
Nefiracetam Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nefiracetam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 282)Lieferanten
77191-36-7()Verwandte Suche:
- n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
- NEFIRACETAM
- 2-oxo-1-pyrrolidinylaceticacid,2,6-dimethylanilide
- dm9384
- dmppa
- n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid
- DM-9384, (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)
- DMMPA
- DZL-221
- Translon
- 2',6'-Dimethyl-2-(2-oxo-1-pyrrolidinyl)acetoanilide
- N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
- (2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide)
- NefiracetaM(Translon)
- 1-PyrrolidineacetaMide,N-(2,6-diMethylphenyl)-2-oxo-
- N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide
- Nefiracetam powder
- Nefiracetam/C14H18N2O2
- Nefiracetam>
- Nefiracetam USP/EP/BP
- Nefiracetam (DM9384
- Racetam Nefiracetam
- TIANFU-CHEM_ Nefiracetam
- Nai the west temple
- 77191-36-7
- 77161-36-7
- Pharmaceutical intermediate
- TRANSLON
- Nootropic
- Smart drug
- BDO
