ANTI-CD137

ANTI-CD137 Struktur
CAS-Nr.
Englisch Name:
ANTI-CD137
Synonyma:
ANTI-4-1BB;ANTI-CD137;ANTI-HUMAN CD137;ANTI-HUMAN 4-1BB;ANTI-CD137 (HUMAN);ANTI-4-1BB (HUMAN);ANTI-TNFRSF 9 (HUMAN);ANTI-CD137 (4-1BB), HUMAN;ANTI-HUMAN CDW137 (4-1BB);ANTI-4-1BB (140-155), MOUSE (RABBIT)
CBNumber:
CB2463610
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-CD137 Eigenschaften

storage temp. 
−20°C
Aggregatzustand
lyophilized powder

Sicherheit

ANTI-CD137 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-CD137 antibody produced in goat is suitable for the following applications:
  • Agonist Activity: Measured by its ability to costimulate IFNg secretion by human T cells in the presence of anti-CD3. The ED50 for this effect is typically 5-20μg/mL.
  • ELISA capture: It can be used as a capturing reagent in a human 4-1BB sandwich immunoassay in combination with biotinylated human 4-1BB detection antibody and recombinant human 4-1BB as the standard. The suggested coating concentration range is 0.2-0.8μg/ml. The recommended concentration of the detection antibody is 0.1-0.4μg/mL.
  • Flow cytometry: 2.5μg/106 cells using Human T cells treated with PHA (phytohemagglutinin).
  • Immunoblotting: A working concentration of 0.1μg/ml was determined using recombinant human CD137.
  • Immunocytochemistry: 5-15μg/mL using immersion fixed human peripheral blood mononuclear cells.

Allgemeine Beschreibung

CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes.

Biochem/physiol Actions

CD137 in T lymphocytes helps to regulate activation, proliferation and apoptosis. CD137 and CD28 are co-stimulatory molecules of T cell activation. It plays an important role in regulating T-cell-dependent immune responses. The expression of CD137 correlates negatively with lymphocyte proliferation and induces cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and helps in prolongs survival.

ANTI-CD137 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-CD137 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 16)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Bohu Biotechnology Co., LTD 021-57763112 13585886131
3004987436@qq.com China 9694 58
AntibodySystem 027-65279366 18162686757
products@biolabreagent.com China 9818 58
ACROBiosystems 18514007688
jiaxin.zhao@acrobiosystems.com China 1002 58

  • ANTI-HUMAN 4-1BB
  • ANTI-HUMAN CD137
  • ANTI-HUMAN CDW137 (4-1BB)
  • ANTI-TNFRSF 9 (HUMAN)
  • ANTI-4-1BB (140-155), MOUSE (RABBIT)
  • ANTI-4-1BB
  • ANTI-4-1BB (HUMAN)
  • ANTI-CD137
  • ANTI-CD137 (4-1BB), HUMAN
  • ANTI-CD137 (HUMAN)
  • Anti-CD137 antibody produced in goat
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