NG 25 (hydrochloride hydrate)

NG 25 (hydrochloride hydrate) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC₅₀s = 21.7 and 149 nM, respectively). It also inhibits the Src family kinases Src and LYN (IC₅₀s = 113 and 12.9 nM, respectively) and Abl family kinases (IC₅₀s = 75.2 nM), as well as CSK, FER, and p38α (IC₅₀s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively, in Gen2.2 cells in a concentration-dependent manner. NG 25 decreases cell viability of HCT116^KRASWT, and to a greater degree of HCT116^KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26^KRASG12D mouse orthotopic model of colorectal cancer.

NG 25 (hydrochloride hydrate) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NG 25 (hydrochloride hydrate) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32070	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58

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• NG 25 (hydrochloride hydrate)