(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
|
|
|
- CAS-Nr.
- 28416-82-2
- Englisch Name:
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- Synonyma:
- FluMethasone acid;Fluticasone Acid;Axon 1170;impurity J;BNKY011-FP01;BNKY012-FF01;Flumetasone acid;flumethason acid;(6a,11b,16a,17a)-6;17-carboxylic acid
- CBNumber:
- CB2854948
- Summenformel:
- C21H26F2O5
- Molgewicht:
- 396.42
- MOL-Datei:
- 28416-82-2.mol
|
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Eigenschaften
- Schmelzpunkt:
- 303-305°C
- Siedepunkt:
- 568.4±50.0 °C(Predicted)
- Dichte
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- Löslichkeit
- Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 3.49±0.70(Predicted)
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitsschädlich bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
|
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate .
Chemische Eigenschaften
White Solid
Verwenden
Fluticasone intermediate. Anti-inflammatory agent
Synthese
To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (Fluticasone 17β-Carboxylic Acid) as a colorless solid.
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 228)Lieferanten
28416-82-2()Verwandte Suche:
- 6a,9a-Difluoro-11b,17a-dihydroxy-16a-methylpregna- 3-oxo-1,4-diene-17b-carboxylic Acid
- Fluticasone 17b-Carboxylic Acid
- 6A,9A-DIFLUORO-11SS,17A-DIHYDROXY-3-OXOANDROSTA-1,4-DIENE-17SS-CARBOXYLIC ACID
- ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6ALPHA,11BETA,16ALPHA,17ALPHA)-
- ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6A,11SS,16A,17A)-
- (6a,11,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
- 6a,9a-Difluoro-11,17a-dihydroxy-16a-methylpregna-3-oxo-1,4-diene-17-carboxylic Acid
- Fluticasone 17-Carboxylic Acid
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-M
- 6a,9a-difluoro-11 P,17a-dihydroxy-16a-methyl-3-
oxoandrosta-1,4-diene-17P-carboxylic acid
- 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid
Discontinued see product # F599490
- Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17- dihydroxy-16-Methyl-3-oxo-,(6|á,11|,16|á,17|á)-
- (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-Methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
- 6α,9α-Difluoro-11β,17α-dihydroxy-16α-Methylpregna-
3-oxo-1,4-diene-17β-carboxylic Acid
- (6A,11B,16A,17A)-6,9-DIFLUORO-11,17-diHYDROXY-16-METHY1-3-OXOANDROSTA-1,4-DIENE-17-CAR
- (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-DIFLUORO-11,17-DIHYDRO
- Fluticasone propionate Intermediates (Flumethasone acid)
- Fluticasone Carboxylic Acid
- (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- (6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxyl
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6α,11β,16α,17α)-
- 6a,9a-Difluoro-1117a-dihydroxy-3-oxoandrosta-1,4-diene-17carboxylic Acid Discontinued see product # F599490
- Axon 1170
- impurity J
- 6α,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
- Fluticasone Impurity 11(Fluticasone USP RC J)
- Fluticasone USP RC J
- Fluticasone 17-beta-Carboxylic Acid
- BNKY011-FP01
- BNKY012-FF01
- Propionate Impurity J
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)
- Fluticasone USP Related Compound J
- Fluticasone IMpurity J
- Fluticasone Propionate Impurity 1
- 1,4-diene-17-carboxylic acid
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid [Flumethasone Acid]
- 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid Discontinued see product # F599490
- Fluticasone 17β-Carboxylic Acid
- Flumetasone acid
- FLUMETHASONE ACID /CAS NO.:28416-82-2
- 6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid
Discontinued see F599490
- 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
- Fluticasone Related Compound J
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-ox...
- Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)-
- (6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
- Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha (1285818)
- FluMethasone acid
- Fluticasone Acid
- flumethason acid
- Fluticasone Propionate USP Related Compound J
- (6a,11b,16a,17a)-6
- Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-
- Fluticasone Propionate Impurity 6
