Siccanin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC
50s = 0.87 and 9.3 μM for
P. aeruginosa and rat mitochondria, respectively). It inhibits the growth of
T. mentagrophytes (IC
50 = 0.3 μg/ml)
via inhibition of succinate oxidation in the mitochondria. It also inhibits the growth of
C. albicans strains with IC
50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.
Verwenden
Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.
Origin
Siccanin was found in the culture broth of Helminthosporium siccans by Sankyo Co. in 1962.
Siccanin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
