metreleptin

metreleptin Struktur
186018-45-1
CAS-Nr.
186018-45-1
Englisch Name:
metreleptin
Synonyma:
metreleptin;Metreleptin impurity A
CBNumber:
CB31349417
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

metreleptin Eigenschaften

Sicherheit

metreleptin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Metreleptin was approved by the Japanese Ministry of Health, Labor and Welfare in March 2013 for the treatment of lipodystrophy and by the US FDA in February 2014 for the treatment of generalized lipodystrophy. Metreleptin is a recombinant N-methionyl analog of the leptin protein; leptin itself was identified via positional cloning in studies on the cause of obesity in the ob/ob mouse strain, which lacks the leptin gene. While there have been many studies of leptin in obesity, this first approval of a leptin analog is directed toward the treatment of lipodystrophy. Toward that end, the effects of leptin administration were studied in a transgenic mouse model of lipodystrophy (with constitutive activation of sterol-regulatory-element-binding-protein- 1c) that results in lack of white adipose tissue. Since, adipocytes serve as a storage depot for triglycerides (TG), the lack of adipocytes results in ectopic lipid deposition in organs such as liver causing hepatomegaly and severe insulin resistance.

Verwenden

Treatment of obesity and related disorders (metabolic homeostasis regulator).

metreleptin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


metreleptin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 5)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21669 55
AFINE CHEMICALS LIMITED
+86-0571-85134551
info@afinechem.com China 15395 58
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2996 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-83725681-603
China 4505 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12338 58

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