(R)-(-)-IBUPROFEN
|
|
- CAS-Nr.
- 51146-57-7
- Englisch Name:
- (R)-(-)-IBUPROFEN
- Synonyma:
- (R)-IBUPROFEN;(R)-2-(4-Isobutylphenyl)propanoic acid;l-Ibuprofen;levibuprofen;(-)-Ibuprofen;(-)-Ibuprophen;2-Yl)carbamate;(R)-(-)-Ibupr en;(R)-(-)-IBUPROFEN;Ibuprofen (R)-Isomer
- CBNumber:
- CB3393273
- Summenformel:
- C13H18O2
- Molgewicht:
- 206.29
- MOL-Datei:
- 51146-57-7.mol
|
(R)-(-)-IBUPROFEN Eigenschaften
- Schmelzpunkt:
- 41-42°C
- Siedepunkt:
- 305.14°C (rough estimate)
- Dichte
- 1.0176 (rough estimate)
- Brechungsindex
- 1.5290 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- Aggregatzustand
- White crystalline powder.
- pka
- 4.41±0.10(Predicted)
- Farbe
- Colourless to Pale Beige Oil
- Wasserlöslichkeit
- 369.3mg/L(25 ºC)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
S-Sätze: |
24/25 |
|
|
HS Code |
29155090 |
|
|
Bildanzeige (GHS) |
|
Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
|
|
Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
|
(R)-(-)-IBUPROFEN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC
50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item
70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC
50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB
4 generation by stimulated neutrophils (IC
50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.
Chemische Eigenschaften
White Crystalline Solid
läuterung methode
Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]
(R)-(-)-IBUPROFEN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R)-(-)-IBUPROFEN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 150)Lieferanten
51146-57-7()Verwandte Suche:
- (R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID
- (R)-(-)-IBUPROFEN
- (-)-Ibuprophen
- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)-
- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)-
- l-Ibuprofen
- R-(-)-p-Isobutylhydratropic acid
- (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid
- Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)-
- (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
- levibuprofen
- Ibuprofen Impurity 20((R)-Isomer)
- (R)-(-)-Ibupr en
- (R)-(-)-Ibuprofen
((R)-Ibuprofen)
- (R)-(-)-ibuprofen reference substance
- Ibuprofen (R)-Isomer
- (R)-(-)-IBUPROFEN USP/EP/BP
- (R)-IbuprofenQ: What is
(R)-Ibuprofen Q: What is the CAS Number of
(R)-Ibuprofen Q: What is the storage condition of
(R)-Ibuprofen Q: What are the applications of
(R)-Ibuprofen
- 5-Triiodo-L-thyronine sodium
- (R)-IBUPROFEN
- (R)-2-(4-Isobutylphenyl)propanoic acid
- (-)-Ibuprofen
- 2-Yl)carbamate
- (αR)?-α-?Methyl-?4-?(2-?methylpropyl)?-benzeneacetic Acid
- 51146-57-7
- 1146-57-7
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Chiral Reagents