TTK21

709676-56-2

CAS-Nr.: 709676-56-2

Englisch Name:: TTK21

Synonyma:: TTK2;TTK21;TTK21(CBP-p300 activator TTK21);Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-;TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300

CBNumber:: CB34666838

Summenformel:: C17H15ClF3NO2

Molgewicht:: 357.75

MOL-Datei:: 709676-56-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 46

TTK21 Eigenschaften

Siedepunkt:: 369.8±42.0 °C(Predicted)

Dichte: 1.321±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml

Aggregatzustand: A crystalline solid

pka: 12.22±0.70(Predicted)

Farbe: White to off-white

InChI: InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)

InChIKey: AQJBXYBDNZHZRE-UHFFFAOYSA-N

SMILES: C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=CC=CC=C1OCCC

Sicherheit

TTK21 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.

Verwenden

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.

TTK21 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TTK21 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 46)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4694	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4264	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3770	55

TTK21
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-
TTK21(CBP-p300 activator TTK21)
TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
TTK2
709676-56-2