Trimethadion Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White, granular, crystalline substance;
camphor-like odor. Soluble in water; freely soluble in alcohol, chloroform, and ether; pH
6.0 (5% solution).
Verwenden
3,5,5-Trimethyloxazolidine-2,4-dione is used in the control of absence (petit mal) seizures that are refractory to treatment with other medications. It is used in the treatment of epilepsy.
Hazard
May have adverse side effects; toxic in
overdose.
Clinical Use
Trimethadione is indicated only for control of absence seizures refractory to treatment with other AEDs. It
is ineffective against other seizure types. Trimethadione is a pro-drug and is metabolized by N-demethylation to dimethadione,
which is effective in the pentylenetetrazole test, which acts by decreasing T-type calcium currents. Trimethadione is rapidly
absorbed, is not protein bound, and has a half-life of 16 to 24 hours. The half-life of dimethadione, however, is substantially
longer (i.e., 6–13 days), and dimethadione accumulates to concentrations greater than the parent drug. Because of its
potentially fatal side effects. including aplastic anemia, nephrosis, idiosyncratic rashes, and exfoliative dermatitis,
trimethadione rarely is used today.
Trimethadion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
