Phensuximid
|
|
|
- CAS-Nr.
- 86-34-0
- Bezeichnung:
- Phensuximid
- Englisch Name:
- PHENSUXIMIDE
- Synonyma:
- pm334;Lifen;Epimid;Lifene;PM 334;Epimal;Mirotin;Milontin;Milonton;Mirontin
- CBNumber:
- CB3480203
- Summenformel:
- C11H11NO2
- Molgewicht:
- 189.21
- MOL-Datei:
- 86-34-0.mol
|
Phensuximid Eigenschaften
- Schmelzpunkt:
- 71-73°
- Siedepunkt:
- 324.47°C (rough estimate)
- Dichte
- 1.1596 (rough estimate)
- Brechungsindex
- 1.5012 (estimate)
- storage temp.
- Refrigerator
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- pka
- -1.86±0.40(Predicted)
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 4.2g/L(25 ºC)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| HS Code |
2925190100 |
|
|
| Toxizität |
LD50 orally in mice: 960 mg/kg (Chen, Ensor) |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
|
Phensuximid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Phensuximide is an anticonvulsant. It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole in mice (ED
50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats. Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Verwenden
Phensuximide, like ethosuximide, is an anticonvulsant drug used in minor forms of
epilepsy.
Clinical Use
Phensuximide occasionally is used for the treatment of absence seizures refractory to other drugs, although it is considered to
be less effective than ethosuximide. It is excreted in both urine and bile, and it may cause harmless pink to red discoloration of
the urine. It should be used with caution in patients with acute intermittent porphyria.
läuterung methode
Crystallise phensuximide from hot 95% EtOH (m 72-73o). At 25o 1g of the imide dissolves in 1g of *C6H6, 18g of Et2O, 9.5g of EtOH, 5.1g of MeOH and 235g of H2O. [Beilstein 21 II 300, 21 III/IV 5465.]
Phensuximid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Phensuximid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 57)Lieferanten
86-34-0(Phensuximid)Verwandte Suche:
- (.+/-.)-N-Methyl-2-phenylsuccinimide
- 1-Methyl-3-phenyl-2,5-pyrrolidinedione
- 1-methyl-3-phenyl-5-pyrrolidinedione
- 1-Methyl-3-phenylpyrrolidin-2,5-dione
- 1-methyl-3-phenyl-pyrrolidine-2,5-quinone
- Phensuximide (500 mg)
- PHENSUCCIMIDE
- 1-Methyl-3-Phenylsuccinimide
- 2,5-Pyrrolidinedione, 1-methyl-3-phenyl-
- Epimid
- Fenosuccimide
- Lifene
- Methylphenylsuccinimide
- Milontin
- Milonton
- Mirontin
- Mirotin
- n-methyl-2-phenyl-succinimid
- N-Methyl-2-phenylsuccinimide
- n-methyl-2-phenyl-succinimide
- N-Methyl-alpha-phenolsuccinimide
- N-Methyl-alpha-phenylsuccinimide
- Phenosuccimide
- Phensuximid
- Phenylsuximide
- PM 334
- pm334
- Succinimide, N-methyl-2-phenyl-
- Succitimal
- PHENSUXIMIDE
- Epimal
- Lifen
- Succitmal
- 5-(Diallylaminomethyl)-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone
- 1-methyl-3-phenyl-pyrrolidine-2,5-dione
- 1-methyl-3-phenylpyrrolidine-2,5-dione
- PHENSUXIMIDE USP/EP/BP
- Phensuximide (1528002)
- AI3 20372
- AI320372
- AI3-20372
- RSYY PHENSUXIMIDE
- 86-34-0
- MILONTIN
