5-(Bis(2-chlorethyl)amino)-2,4-(1H,3H)-pyrimidin-dion

URACIL  MUSTARD  Struktur
66-75-1
CAS-Nr.
66-75-1
Bezeichnung:
5-(Bis(2-chlorethyl)amino)-2,4-(1H,3H)-pyrimidin-dion
Englisch Name:
URACIL MUSTARD
Synonyma:
U-8344;CB-4835;ent50439;Nordopan;SK-19849;NSC-34462;Uramustin;ENT 50439;NCI-C04820;Uracillost
CBNumber:
CB3500556
Summenformel:
C8H11Cl2N3O2
Molgewicht:
252.1
MOL-Datei:
66-75-1.mol

5-(Bis(2-chlorethyl)amino)-2,4-(1H,3H)-pyrimidin-dion Eigenschaften

Schmelzpunkt:
206°C (rough estimate)
Dichte
1.6350 (rough estimate)
Brechungsindex
1.6100 (estimate)
Löslichkeit
DMSO (Sparingly), Methanol (Slightly, Heated)
Aggregatzustand
Solid
pka
9.42±0.10(Predicted)
Farbe
Crystals from MeOH (aq)
IARC
2B (Vol. 9, Sup 7) 1987
EPA chemische Informationen
Uracil mustard (66-75-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  3249
HazardClass  6.1(a)
PackingGroup  I
Giftige Stoffe Daten 66-75-1(Hazardous Substances Data)
Toxizität LD50 i.p. in rats: ~1.25-2.5 mg/kg (Chaube, Murphy)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augenschäden. Schwere Augenschädigung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P321 Besondere Behandlung
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5-(Bis(2-chlorethyl)amino)-2,4-(1H,3H)-pyrimidin-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Uracil mustard appears as creamy/off-white, odourless, crystalline powder. It is used as an anti-cancer medicine. Uracil mustard is a chemotherapy drug that belongs to the class of alkylating agents. It is used for its anti-neoplastic properties. It works by damaging deoxyribonucleic acid (DNA), primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. The DNA damage leads to apoptosis of the affected cells. Chemically it is a derivative of nitrogen mustard and uracil. Uracil mustard is a non-combustible substance itself; it does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidisers and may ignite combustibles – wood, paper, oil, clothing, etc. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Verwenden

Antineoplastic.

Allgemeine Beschreibung

Creamy white crystals or off-white powder. Used as an anti-cancer medicine.

Air & Water Reaktionen

Slightly soluble in water [Merck].

Reaktivität anzeigen

URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY) reacts as a base.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Brandgefahr

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Sicherheitsprofil

Suspected carcinogen withexperimental carcinogenic and neoplastigenic data. Adeadly poison by ingestion and intraperitoneal routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of Cl?? and NOx.

Carcinogenicity

Uracil mustard was reportedly carcinogenic in both mice and rats following multiple intraperitoneal injections. It produced a dose-related increase in lung tumor incidence in mice and tumors in a variety of other organs in both mice and rats. The IARC reviewed the preceding data and deemed it “sufficient evidence of carcinogenicity in animals.” Based on this information, its mutagenic potential, analogy to other nitrogen mustards, and a lack of carcinogenicity data in humans, the IARC classified uracil mustard in Group 2B (possibly carcinogenic to humans). Uracil mustard compared to nitrogen mustard itself in the same assay (lung tumor assay in strain A mice, intraperitoneal dosing) was found to be more potent as a tumorigen than nitrogen mustard. An in vitro assay to predict carcinogenicity gave a positive response predicting that uracil mustard would be a carcinogen in rodent test models. The assay used focus formation in a stable bovine papillomavirus type 1 DNA carrying a mouse fibroblast cell line that does not require transfection, infection with virus,isolation of primary cells from animals, or addition of a microsomal fraction.

5-(Bis(2-chlorethyl)amino)-2,4-(1H,3H)-pyrimidin-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

66-75-1(5-(Bis(2-chlorethyl)amino)-2,4-(1H,3H)-pyrimidin-dion)Verwandte Suche:


  • 5-N,N-Bis(2-chloroethyl)aminouracil Desmethyldopan
  • 2,4-(1H,3H)-Pyrimidinone, 5-[bis(2-chloroethyl)amino]
  • UNAMUSTINE(URACIL MUSTARD)
  • URASILMUSTARD
  • 2,4(1H,3H)-Pyrimidinedione, 5-[bis(2-chloroethyl)amino]-
  • 2,6-dihydroxy-5-bis(2-chloroethyl)aminopyramidine
  • 3h)-pyrimidinedione,5-(bis(2-chloroethyl)amino)-4(1h
  • 5-(Bis(2-chlorethyl)amino)-2,4(1H,3H)pyrimidinedione
  • ent50439
  • NCI-C04820
  • Nordopan
  • NSC-34462
  • Rcra waste number U237
  • rcrawastenumberu237
  • SK-19849
  • U-8344
  • Uracil Mustard
  • Uracil nitrogen mustard
  • Uracillost
  • Uracilmostaza
  • uracilmustard
  • uracilnitrogenmustard
  • Uramustin
  • Uramustine
  • URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY)
  • 5-(Bis(2-chloroethyl)amino)-2,4(1H,3H)pyrimidinedione
  • 5-(bis(2-chloroethyl)amino)-2,4-(1h,3h)-pyrimidinedione
  • 5-(bis(2-chloroethyl)amino)-uraci
  • 5-(Di(2-chloroethyl)amino)uracil
  • 5-(di-(beta-chloroethyl)amino)uracil
  • 5-(di-2-chloroethyl)aminouracil
  • 5-[Di(beta-chloroethyl)amino]uracil
  • 5-aminouracilmustard
  • Aminouracil mustard
  • aminouracilmustard
  • CB-4835
  • Chlorethaminacil
  • Demethyldopan
  • ENT 50439
  • 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
  • Uraphetinum
  • 5-[Bis(2-chloroethyl)amino]pyrimidine-2,4-diol
  • URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY) USP/EP/BP
  • Uramustine (Uracil mustard)
  • 5-(Bis(2-chloroethyl)amino)pyrimidine-2,4(1H,3H)-dione
  • Uramustina
  • Uramustine (INN)
  • Uramustinum
  • Uracil lost [Germ
  • URACIL MUSTARD; DEMETHYLDOPAN; DESMETHYLDOPAN; URACILMOSTAZA; URACILLOST; URAMUSTIN; NORDOPAN; CHLORETHAMINACIL; AMINOURACIL MUSTARD; URAMUSTINA; URAMUSTINUM; URACIL LOST; URACIL NITROGEN MUSTARD; 5-AMINOURACIL MUSTARD; URAMUSTINE (INN); URACIL LOST [GERM
  • 66-75-1
  • C8H11Cl2N3O2
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