Armodafinil
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- CAS-Nr.
- 112111-43-0
- Englisch Name:
- Armodafinil
- Synonyma:
- Nuvigil;CRL 40982;CEP 10952;R MODAFINIL; Armodafinil;Modafinil R-Isomer;Armodafinil CIV (500 mg);2-[(R)-benzhydrylsulfinyl]acetamide;(R)-2-(benzhydrylsulfinyl)acetamide;2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide
- CBNumber:
- CB3500844
- Summenformel:
- C15H15NO2S
- Molgewicht:
- 273.35
- MOL-Datei:
- 112111-43-0.mol
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Armodafinil Eigenschaften
- Schmelzpunkt:
- 156-1580C
- Siedepunkt:
- 559.1±50.0 °C(Predicted)
- Dichte
- 1.283
- storage temp.
- Controlled Substance, -20°C Freezer
- Löslichkeit
- DMSO: ≥16mg/mL
- pka
- 14.88±0.40(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to tan
- Optische Aktivität
- [α]/D -15 to -20° in methanol (C=1)
Armodafinil Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Armodafinil, an α1-adrenoceptor agonist, was launched for the
oral treatment of excessive sleepiness associated with narcolepsy, SWSD, and
obstructive sleep apnea/hypopnea syndrome (OSA). It is the R-enantiomer
of modafinil, which is a previously marketed wake-promoting agent. The key
differentiator for armodafinil is its longer pharmacokinetic half-life as
compared with the S-enantiomer (10-14 hvs.3-4h). At therapeutic
concentrations, armodafinil does not bind to most of the potentially
relevant receptors for sleep/wake regulation (e.g., serotonin, dopamine,
and adenosine receptors) or transporters of neurotransmitters or enzymes
involved in sleep/wake regulation (e.g., serotonin, norepinephrine, and
phosphodiesterase VI transporters). Both armodafinil and modafinil block
dopamine reuptake by binding to the dopamine transporter and increasing
dopamine concentrations in certain regions of the brain. However, dopamine
receptor antagonists (e.g., haloperidol) and dopamine synthesis inhibitors
(e.g., α-methyl-p-tyrosine) do not block modafinil’s action.
In addition to its wake-promoting effects and ability to increase locomotor activity in animals, modafinil produces psychoactive and euphoric effects, alterations in mood, perception, thinking, and feelings typical of other CNS stimulants in humans. Modafinil was also partially discriminated as stimulant-like. However, the potential for abuse and dependency appears to be lower for modafinil than amphetamine-like stimulants.The most common adverse
events associated with armodafinil included headache, nausea, dizziness,
and insomnia.
Chemische Eigenschaften
White Solid
Verwenden
Used for treatment of excessive sleepiness, a1-adrenoceptor agonist
Definition
ChEBI: A 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disord
r. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness.
Armodafinil Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
112111-43-0()Verwandte Suche:
- R MODAFINIL
- Armodafinil
- 2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide
- CEP 10952
- CRL 40982
- Nuvigil
- AcetaMide,2-[(R)-(diphenylMethyl)sulfinyl]-
- 2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide, CEP 10952, CRL 40982, Nuvigil
- (R)-2-(benzhydrylsulfinyl)acetamide
- 2-[(R)-benzhydrylsulfinyl]acetamide
- Modafinil R-Isomer
- ArmodafinilQ: What is
Armodafinil Q: What is the CAS Number of
Armodafinil Q: What is the storage condition of
Armodafinil Q: What are the applications of
Armodafinil
- R-Modafinil D10Q: What is
R-Modafinil D10 Q: What is the CAS Number of
R-Modafinil D10 Q: What is the storage condition of
R-Modafinil D10 Q: What are the applications of
R-Modafinil D10
- Armodafinil CIV (500 mg)
- *Buprenorphine Impurity 5 (Buprenorphine EP Impurity E)
- 112111-43-0
- NUVIGIL
- Chiral Reagents
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
