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H-7 DIHYDROCHLORIDE

H-7 DIHYDROCHLORIDE Struktur
108930-17-2
CAS-Nr.
108930-17-2
Englisch Name:
H-7 DIHYDROCHLORIDE
Synonyma:
H-7;H-7 DIHYDROCHLORIDE;H-7 (hydrochloride);H-7 dihydrochloride,98%;H7 dihydrochloride,H 7 dihydrochloride;Protein kinase inhibitor H-7 dihydrochloride;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
CBNumber:
CB3725838
Summenformel:
C14H19Cl2N3O2S
Molgewicht:
364.29
MOL-Datei:
108930-17-2.mol
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H-7 DIHYDROCHLORIDE Eigenschaften

Schmelzpunkt:
215-225 °C
storage temp. 
2-8°C
Löslichkeit
H2O: 20 mg/mL
Aggregatzustand
Light yellow lyophilized solid
Farbe
White to Off-White
BRN 
5840763
CAS Datenbank
108930-17-2(CAS DataBase Reference)

Sicherheit

S-Sätze: 24/25
WGK Germany  3
F  10

H-7 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Definition

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

Allgemeine Beschreibung

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

H-7 DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

H-7 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 73)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30253 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32360 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32344 50
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
China 9900 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80

108930-17-2()Verwandte Suche:

2-Methylpiperazin Piperazindihydrochlorid 1-(m-Tolyl)piperazindihydrochlorid 10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid 1,4-Phenylendiamin-dihydrochlorid 1,4'-Bipiperidindihydrochlorid 1,3-Propandiamindihydrochlorid 1-(3-Methoxyphenyl)piperazindihydrochlorid Tetramethylendiammoniumdichlorid 1-[3-(Trifluormethyl)phenyl]piperaziniumchlorid 1,3-Phenylendiamin-dihydrochlorid (Tetrahydro-1H-1,4-diazepin-1,4(5H)-diyl)di(propan-1,3-diyl)bis(3,4,5-trimethoxybenzoat)dihydrochlorid
  • H-7 DIHYDROCHLORIDE
  • H-7
  • (+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
  • 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE
  • (+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
  • 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
  • (-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT
  • (+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
  • 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
  • 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl
  • H-7 dihydrochloride,98%
  • Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
  • 5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline Hydrochloride
  • H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
  • H-7 (hydrochloride)
  • H7 dihydrochloride,H 7 dihydrochloride
  • 5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride
  • Protein kinase inhibitor H-7 dihydrochloride
  • 108930-17-2
  • C14H19Cl2N3O2S
  • Cell Biology
  • Serine/Threonine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Protein kinase A and protein kinase C (PKA and PKC)
  • BioChemical
  • Cell Signaling and Neuroscience
  • Protein Kinase Inhibitors and Activators
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