9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R26:Sehr giftig beim Einatmen.
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity. Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-
dehydrocholesterol to vitamin D
3 by ultraviolet light. Vitamin D
2 is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D
2 is metabolized first to 25-
hydroxyvitamin D
2 and subsequently to the active 1,25-
dihydroxyvitamin D
2. Differences in the metabolism and action of vitamin D
2 vs. vitamin D
3 in mammals is a current topic of research interest.
Chemische Eigenschaften
Ergocalciferol is an odorless white crystalline
solid
Verwenden
Vitamin d2 is fat-soluble, and is stable unless oxidized. It is necessary for growth and maintenance of teeth and bones and the normal utilization of calcium and phosphorus; it is used medicinally in the treatment of rickets and as a dietary supplement. Its sources include fish liver and vitamin d-fortified milk.
Definition
ChEBI: A vitamin D supplement and has been isolated from alfalfa.
Allgemeine Beschreibung
Odorless white crystals. Used as a dietary supplement and food additive.
Reaktivität anzeigen
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Health Hazard
Vitamin D2 poisoning disturbs calcium metabolism and causes kidney damage. Vitamin D2 in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D. Those with hypercalcemia are at a greater risk.
Brandgefahr
Shows signs of decomposition when stored for a few days at room temperature.
Sicherheitsprofil
Poison by ingestion,
intraperitoneal, intravenous, and
intramuscular routes. An experimental
teratogen. Human systemic effects by
ingestion: anorexia, nausea or vomiting, and
weight loss. Experimental reproductive
effects. When heated to decomposition it
emits acrid smoke and irritating fumes.
mögliche Exposition
Used as a nutrient and/or dietary supplement food additive
Stoffwechselwegen
Ergocalciferol (vitamin D2) is a product made by the UV irradiation of
yeast ergosterol. It is a common form of vitamin D and it has very similar
biological activity to that of cholecalciferol (vitamin D3) in the treatment of
the vitamin D deficiency diseases (e.g. rickets). The bioactive form of this
vitamin is also the 1,25-dihydroxy-derivative and this has equal antirachitic
activity to that of the cholecalciferol analogue (Jones et al., 1975).
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN3249 Medicine, solid, toxic, n.o.s.,
Hazard Class: 6.1; Labels: 6.1-Poisonous materials
läuterung methode
It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 IV 4404.]
Inkompatibilitäten
Dust may be combustible and may form
explosive mixture with air. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, strong
bases, strong acids, oxoacids, and epoxides.
Waste disposal
Dispose of contents and container to an approved waste disposal plant. All federal,
state, and local environmental regulations must be
observed. It is inappropriate and possibly dangerous to the
environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding
them to the trash. Household quantities of expired or waste
pharmaceuticals may be mixed with wet cat litter or coffeegrounds, double-bagged in plastic, discard in trash. Larger
quantities shall carefully take into consideration applicable
DEA, EPA, and FDA regulations. If possible return the
pharmaceutical to the manufacturer for proper disposal
being careful to properly label and securely package the
material. Alternatively, the waste pharmaceutical shall be
labeled, securely packaged and transported by a state
licensed medical waste contractor to dispose by burial in a
licensed hazardous or toxic waste landfill or incinerator.
9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
25-HYDROXYVITAMIN D2
VitaMin D2 Tosylate
(1R,3aR,7aR)-1-((2R,5S)-5,6-diMethylheptan-2-yl)-7a-Methyloctahydro-1H-inden-4-ol
Vitamin D2 SO2 Adduct
(3S)-1,3-Bis-O-tert-ButyldiMethylsilyl 3-Hydroxy VitaMin D2 SO2 Adduct (Mixture of DiastereoMers)
tert-Butyl-dimethyl-{3-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2l6-benzo[c]thiophen-5-yloxy}-silane
