Tolpropaminhydrochlorid

tolpropamine hydrochloride Struktur
3339-11-5
CAS-Nr.
3339-11-5
Bezeichnung:
Tolpropaminhydrochlorid
Englisch Name:
tolpropamine hydrochloride
Synonyma:
Tolpropamine HCl;Einecs 222-082-9;tolpropamine hydrochloride;tolpropamine hydrochloride USP/EP/BP
CBNumber:
CB3875256
Summenformel:
C18H23N.ClH
Molgewicht:
0
MOL-Datei:
Mol file

Tolpropaminhydrochlorid Eigenschaften

Schmelzpunkt:
162-164 °C

Sicherheit

Tolpropaminhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Tolpropamine,Hoechst (Aventis)

Manufacturing Process

The Grignard solution (prepared from 53 g bromtoluene and 7.2 g magnesium in 300 ml of ether) was added dropwise to a solution of 35 g β- dimethylaminopropiophenone in 50 ml ether. The mixture was refluxed for 3 hours. Then the liquid phase was added to 500 parts of ice and 100 parts concentrated hydrochloric acid. 1-Phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was crystallized. M.P. of hydrochloride of 1-phenyl-1-p-tolyl-3- dimethylaminopropanol-1 185°C.
10 g of 1-phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was dissolved in 30 ml of 85% phosphoric acid and the solution was heated at 130-135°C for 1 hour. After cooling to the mixture was added a water and an aqueous solution of sodium hydroxide. γ-Phenyl-γ-p-tolylallyldimethylamine was extracted with ether and extract was dried with sodium sulfate. γ-Phenyl-γ-p-tolylallyldimethylamine hydrochloride was hydrogenated with palladium catalyst. γ-Phenyl-γ-p-tolyl-3-dimethylaminopropan obtained has melting point 156°C.

Therapeutic Function

Antihistaminic, Antipruritic

Tolpropaminhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tolpropaminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • tolpropamine hydrochloride
  • Einecs 222-082-9
  • Tolpropamine HCl
  • tolpropamine hydrochloride USP/EP/BP
  • 3339-11-5
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