1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Struktur
241127-58-2
CAS-Nr.
241127-58-2
Englisch Name:
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
Synonyma:
Adaphostin;1-Adamantyl 4-((2;5-Dihydroxybenzyl)Amino)Benzoate;1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate;1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate;4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester;Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
CBNumber:
CB41456086
Summenformel:
C24H27NO4
Molgewicht:
393.48
MOL-Datei:
241127-58-2.mol

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Eigenschaften

storage temp. 
Desiccate at +4°C
Löslichkeit
DMSO: soluble20mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Novel antitumor agent that induces apoptosis in tumor cells through inhibition of the tyrosine kinase BCR/ABL.

Biologische Aktivität

p210 bcr/abl tyrosine kinase inhibitor (IC 50 = 14 μ M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 values range from 16.8 to 216.3 nM) in vitro . Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro .

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 42)Lieferanten
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ATK CHEMICAL COMPANY LIMITED
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TargetMol Chemicals Inc.
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Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8474 58
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757984502@qq.com China 892 58
Aladdin Scientific
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
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Chemsky (shanghai) International Co.,Ltd 021-50135380
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EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60

  • 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
  • 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester
  • Adaphostin
  • 5-Dihydroxybenzyl)Amino)Benzoate
  • 1-Adamantyl 4-((2
  • Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester
  • 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate
  • Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
  • 241127-58-2
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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