3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on
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- CAS-Nr.
- 60-82-2
- Bezeichnung:
- 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on
- Englisch Name:
- Phloretin
- Synonyma:
- Floretin;Phloretol;Dihydronaringenin;3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one;oretin;RJC 02792;PHLORETIN;Phloridin;Asebogenol;NSC 407292
- CBNumber:
- CB4161608
- Summenformel:
- C15H14O5
- Molgewicht:
- 274.27
- MOL-Datei:
- 60-82-2.mol
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3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on Eigenschaften
- Schmelzpunkt:
- ~260 °C
- Siedepunkt:
- 337.26°C (rough estimate)
- Dichte
- 1.1827 (rough estimate)
- FEMA
- 4390 | 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE
- Brechungsindex
- 1.573-1.575
- storage temp.
- 2-8°C
- Löslichkeit
- Acetonitrile (Slightly), Methanol (Slightly)
- pka
- 7.16±0.40(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White to beige
- Geruch (Odor)
- odorless
- Wasserlöslichkeit
- soluble
- Merck
- 14,7326
- JECFA Number
- 2022
- BRN
- 1887240
- InChIKey
- VGEREEWJJVICBM-UHFFFAOYSA-N
- LogP
- 3.50
- CAS Datenbank
- 60-82-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
37/39-26-36 |
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| WGK Germany |
3 |
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| F |
3-10 |
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| HazardClass |
IRRITANT |
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| HS Code |
29145090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Phloretin has been used:
- to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake
- to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay
- as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro
Verwenden
As glucose transport inhibitor, Phloretin can inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts.
Definition
ChEBI: Phloretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. It has a role as a plant metabolite and an antineoplastic agent. It is functionally related to a dihydrochalcone.
Allgemeine Beschreibung
Phloretin is a dihydrochalcone flavonoid with antioxidant activity usually found in apples and apple-derived products. It is extensively used for peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.
läuterung methode
Crystallise phloretin from aqueous EtOH. [Zemplen & Bognár Chem Ber 75 1040 1942, Zemplén Chem Ber 76 386 1943, Beilstein 8 IV 3518.]
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 474)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD
|
15202951039
|
jason@sgonekbio.com |
China |
268 |
58 |
|
Hebei Weibang Biotechnology Co., Ltd
|
+8615531157085
|
abby@weibangbio.com |
China |
8816 |
58 |
|
Hebei Chuanghai Biotechnology Co,.LTD
|
+86-13131129325
|
sales1@chuanghaibio.com |
China |
5893 |
58 |
|
Bonerge(Hunan) Lifescience Co., Ltd.
|
+86-731-82791134 +86-18801900056
|
hank.h@bonerge.com |
China |
30 |
58 |
|
Shaanxi Haibo Biotechnology Co., Ltd
|
+undefined18602966907
|
qinhe02@xaltbio.com |
China |
997 |
58 |
|
Chongqing Zhihe Biopharmaceutical Co., Ltd.
|
+8618580541567
|
sales@zhswyy.com |
China |
303 |
58 |
|
Henan Fengda Chemical Co., Ltd
|
+86-371-86557731 +86-13613820652
|
info@fdachem.com |
China |
20288 |
58 |
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
+8618092446649
|
sarah@tnjone.com |
China |
1143 |
58 |
|
BINBO BIOLOGICAL CO.,LTD
|
+8618629063126
|
info@binbobiological.com |
China |
356 |
58 |
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
+8613343047651
|
admin@zlchemi.com |
China |
3002 |
58 |
60-82-2(3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-on)Verwandte Suche:
p-Methylpropiophenon
2,2,6,6-Tetramethyl-4-piperidon
1,1,3-Trichloraceton
2,2'-[Oxybis(methylen)]bis[2-ethylpropan-1,3-diol]
3'-Hydroxypropiophenon
Puerarin
Trometamol
α,α,α-Trifluor-p-kresol
Citric acid monohydrate
Propylidintrimethanol
1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-on
2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon
(S)-7-[[6-O-(6-Desoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-on
(S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron
2,4,6-Trinitrophenol
Propiophenon
(S)-7-[[6-O-(6-Desoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-4H-benzopyran-4-on
(S)-7-[[2-O-(6-Desoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-4H-benzopyran-4-on
- 2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone
- Phloretin,98%
- β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone
- PHLORETIN(RG)
- 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-
- trihydroxyphenyl)-
- β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, 2μ,4μ,6μ-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
- 2',4,4',6'-Tetrahydroxy-α,β-dihydro-trans-chalcone
- Phloretin,β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)propiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
- Phloretin(Dihydronaringenin)
- 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
- Asebogenol
- NSC 407292
- RJC 02792
- Phloretin Synonyms 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
- 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
- Phloretin
2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone
- PHLORETIN
- PHLORETIN (NATURAL)
- METHYL-4-4-(4-HYDROXYDIPHENYL METHYL)-PIPERIDINE-1-OXOBUTYL-2,2-DIMETHYLPHENYL ACETIC ACID.FEXOFENADINE INTERMEDIATE
- 2',4',6',4-TETRAHYDROXYDIHYDROCHALCONE
- 2,4,6-TRIHYDROXY-BETA-(4-HYDROXYPHENYL)PROPIOPHENONE
- 2',4',6'-TRIHYDROXY-3-P-HYDROXYPHENYLPROPIOPHENONE
- 2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-1-PROPIOPHENONE
- 2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)-PROPIOPHENONE
- BETA-(4-HYDROXYPHENYL)-2,4,6-TRIHYDROXY-PROPIOPHENONE
- 4,2',4',6'-TETRAHYDROXYDIHYDROCHALCONE
- 3-[4-HYDROXYPHENYL]-1-[2,4,6-TRIHYDROXYPHENYL]-1-PROPANONE
- Phloridin
- Water-Soluble Phloretin
- Phloretin Nano-Liposome
- oretin
- Phloretin, 98.0+ % (HPLC)
- Phloretin>
- Phloretin 60-82-2
- Phloretin - CAS 60-82-2 - Calbiochem
- Phloretin 60-82-2 Natural Plant Extracts
- factory Phloretin 60-82-2
- Liposomal Phloretin,Water Soluble Phloretin,NanoActive Phloretin, Phloretin NanoEmulsion
- Nanoactive Phloretin
- Nano Liposomal Phloretin
- 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
- Dihydronaringenin
- Floretin
- Phloretol
- Phloretin (6CI)
- Icaritin Impurity 7
- Phloretin (RJC 02792)
- Dihydronaringenin|||NSC 407292|||RJC 02792
- 2'-(beta-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
- Phloretin-RM
- 60-82-2
- 80-82-2
- 60-82-8
- 1934-21-1
- Voltage-gated Ion Channels
- Organic Building Blocks
- Inhibitors and Activators
