PF 573228
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- CAS-Nr.
- 869288-64-2
- Englisch Name:
- PF 573228
- Synonyma:
- PF-228;CS-253;PF 573228;PF-573228, >=98%;PF-573228 ，S2013;PF-573228[PZ0117];PF-573228;PF 573228;PF 573228 USP/EP/BP;PF-573228
DISCONTINUED;PF-573228, 10 mM in DMSO
- CBNumber:
- CB42459138
- Summenformel:
- C22H20F3N5O3S
- Molgewicht:
- 491.49
- MOL-Datei:
- 869288-64-2.mol
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PF 573228 Eigenschaften
- Schmelzpunkt:
- >242°C (dec.)
- Dichte
- 1.459
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- pka
- 14.30±0.20(Predicted)
- Farbe
- white to off-white
- InChIKey
- HESLKTSGTIBHJU-UHFFFAOYSA-N
- SMILES
- CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1
PF 573228 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC
50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.
Verwenden
A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.
Biochem/physiol Actions
PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.
PF 573228 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PF 573228 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 173)Lieferanten
- PF 573228
- 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
- 6-[(4-((3-(Methanesulfonyl)benzyl)aMino)-5-trifluoroMethylpyriMidin-2-yl)aMino]-3,4-dihydro-1H-quinolin-2-one
- 6-((4-((3-(Methylsulfonyl)benzyl)aMino)-5-(trifluoroMethyl)pyriMidin-2-yl)aMino)-3,4-dihydroquinolin-2(1H)-one
- 2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
- Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one PF573228
- PF 573228
6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]-3,4-dihydro-1H-quinolin-2-one
- PF-228
- PF-573228, >=98%
- PF-573228;PF 573228
- 3,4-DIHYDRO-6-[[4-[[[3-(METHYLSULFONYL)PHENYL]METHYL]AMINO]-5-(TRIFLUOROMETHYL)-PYRIMIDIN-2-YL]AMINO]-2(1H)-QUINOLINONE
- 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]
- Focal Adhesion Kinase Inhibitor II
- CS-253
- Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem
- 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one
- PF 573228 USP/EP/BP
- PF-573228
DISCONTINUED
- PF-573228 PF573228 Focal Adhesion Kinase Inhibitor II
- PF-573228, 10 mM in DMSO
- PF-573228 ，S2013
- PF-573228[PZ0117]
- FAK inhibitor (PF-573228)
- 869288-64-2
- C22H20F3N5O3S
- Amines
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pfizer Compounds
- Pharmaceuticals
